Faculty Information, Institute for Chemical Research, Kyoto University   [ English | Japanese ]


WATANABE, Bunta

Division of Biochemistry - Chemistry of Molecular Biocatalysts -
Assistant Professor
Doctor of Agricultural Science, Kyoto University (2004)
URL:http://biofun.kuicr.kyoto-u.ac.jp/index-e.html
E-mail: bunta@scl.kyoto-u.ac.jp
Tel: 0774-38-3233
Fax: 0774-38-3229
Academic career
    Assistant Professor, Institute for Chemical Research, Kyoto University, 1 March 2009-present.
    Research Scientist, Sagami Chemical Research Center, 24 November 2005-28 February 2009.
    Post-Doctoral Research Fellow, Graduate School of Agriculture, Kyoto University, 17 January 2005-23 November 2005.
    Post-Doctoral Research Fellow, Institute for Chemical Research, Kyoto University, 1 April 2004-16 January 2005.
Research field
    Organic synthesis
Current research
  1. Synthesis of bioactive compounds
  2. Synthesis of enzyme inhibitors and their application
Selected publications
  1. Yamamoto, S.; Watanabe, B.; Hiratake, J.; Tanaka, R.; Ohkita, M.; Matsumura, Y., Preventive Effect of GGsTop, a Novel and Selective γ-Glutamyl Transpeptidase Inhibitor, on Ischemia/Reperfusion-Induced Renal Injury in Rats J. Pharmacol. Exp. Ther. 339, 945-951 (2011)  [pubmed]
  2. Koeduka, T.; Watanabe, B.; Suzuki, S.; Hiratake, J.; Mano, J.; Yazaki, K., Characterization of Raspberry Ketone/Zingerone Synthase, Catalyzing the alpha, beta-Hydrogenation of Phenylbutenones in Raspberry Fruits. Biochem. Biophys. Res. Commun. 412, 104-108 (2011)  [pubmed]
  3. Arai, H.; Watanabe, B.; Nakagawa, Y.; Miyagawa, H., Synthesis of Ponasterone A Derivatives with Various Steroid Skeleton Moieties, Evaluation of their Binding to the Ecdysone Receptor of Kc Cells. Steroids 73, 1452-1464 (2008)  [pubmed]
  4. Todoroki, Y.; Kobayashi, K.; Yoneyama, H.; Hiramatsu, S.; Jin, M -H.; Watanabe, B.; Mizutani, M.; Hirai, N., Structure-Activity Relationship of Uniconazole, a Potent Inhibitor of ABA 8′-Hydroxylase, with a Focus on Hydrophilic Functional Groups and Conformation. Bioorg. Med. Chem. 16, 3141-3152 (2008)  [pubmed]
  5. Murakami, K.; Watanabe, B.; Nishida, R.; Mori, N.; Kuwahara, Y., Identification of Crinosterol from Astigamatid Mites. Insect Biochem. Molecular Biol. 37, 506-511 (2007)  [pubmed]
  6. Ohnishi, T.; Szatmari, A M.; Watanabe, B.; Fujita, S.; Bancos, S.; Koncz, C.; Lafos, M.; Shibata, K.; Yokota, T.; Sakata, K.; Szekeres, M.; Mizutani, M., C-23 Hydroxylation by Arabidopsis CYP90C1 and CYP90D1 Reveals a Bovel Shortcut in Brassinosteroid Biosynthesis. Plant Cell 18, 3275-3288 (2006)  [pubmed]
  7. Ohnishi, T.; Watanabe, B.; Sakata, K.; Mizutani, M., CYP724B2 and CYP90B3 Function in the Early C-22 Hydroxylation Steps of Brassinosteroid Biosynthetic Pathway in Tomato. Biosci. Biotechnol. Biochem. 70, 2071-2080 (2006)  [pubmed]
  8. Ohnishi, T.; Nomura, T.; Watanabe, B.; Ohta, D.; Yokota, T.; Miyagawa, H.; Sakata, K.; Mizutani, M., Tomato Cytochrome P450 CYP734A7 Functions in Brassinosteroid Catabolism. Phytochem. 67, 1895-1906 (2006)  [pubmed]
  9. Morikawa, T.; Mizutani, M.; Aoki, N.; Watanabe, B.; Saga, H.; Saito, S.; Oikawa, A.; Suzuki, H.; Sakurai, N.; Shibata, D.; Wadano, A.; Sakata, K.; Ohta, D., Cytochrome P450 CYP710A Encodes the Sterol C-22 Desaturase in Arabidopsis and Tomato. Plant Cell 18, 1008-1022 (2006)  [pubmed]
  10. Fujita, S.; Ohnishi, T.; Watanabe, B.; Yokota, T.; Takatsuto, S.; Fujioka, S.; Yoshida, S.; Sakata, K.; Mizutani, M., Arabidopsis CYP90B1 Catalyzes the Early C-22 Hydroxylation of C27, C28, and C29 Sterols. Plant J. 45, 765-774 (2006)  [pubmed]
  11. Yamamoto, S.; Watanabe, B.; Otsuki, J.; Nakagawa, Y.; Akamatsu, M.; Miyagawa, H., Synthesis of 26,27-Bisnorcastasterone Analogs and Analysis of Conformation-Activity Relationship for Brasssinolide-like Activity. Bioorg. Med. Chem. 14, 1761-1770 (2006)  [pubmed]
  12. Watanabe, B.; Nakagawa, Y.; Ogura, T.; Miyagawa, H., Stereoselective Synthesis of (22R)- and (22S)-Castasterone/Ponasterone A Hybrid Compounds and Evaluation of their Molting Hormone Activity. Steroids 69, 483-493 (2004)  [pubmed]
  13. Uesusuki, S.; Watanabe, B.; Yamamoto, S.; Otsuki, J.; Nakagawa, Y.; Miyagawa, H., Synthesis of Brassinosteroids of Varying Acyl Side Chains andEvaluation of their Brassinolide-like Activity Biosci. Biotechnol. Biochem. 68, 1097-1105 (2004)  [pubmed]
  14. Watanabe, B.; Yamamoto, S.; Sasaki, K.; Nakagawa, Y.; Miyagawa, H., A Simple Synthesis of 6-Deoxoteasterone and its 20-Epimer. Tetrahedron Lett. 45, 2767-2769 (2004)
  15. Watanabe, B.; Nakagawa, Y.; Miyagawa, H., Synthesis of a Castasterone/Ponasterone Hybrid Compound and Evaluation of its Molting Hormone-like Activity. J. Pestic. Sci. 28, 188-193 (2003)
  16. Miyagawa, H.; Okada, M.; Uemura, I.; Watanabe, B.; Ueno, T., A Chemical Approach for Elucidating the Molecular Interaction of Host-Specific AK-Toxin with Japanese Pear. Advances in Microbial Toxin Research and its Biotechnological Exploitation (Kluwer Academic/Plenum Publishers) 1-21 (2002)

Update: Apr 02,2012