京都大学化学研究所研究者情報   [ English | Japanese ]


渡辺 文太 (わたなべ ぶんた )

生体機能化学研究系 生体触媒化学
助教
博士(農学)
URL:http://www.scl.kyoto-u.ac.jp/~bunta/index-j.html
E-mail: bunta (at) scl.kyoto-u.ac.jp
Tel: 0774-38-3233
Fax: 0774-38-3229

研究・教育歴
    平成16年4月〜平成17年1月 京都大学化学研究所講師(研究機関研究員)
    平成17年1月〜平成17年11月 京都大学大学院農学研究科21世紀COE研究員(昆虫化学が拓く未来型食料環境学の創生)
    平成17年11月〜平成21年2月 公益財団法人相模中央化学研究所研究員(創薬化学グループ)
    平成21年3月〜現在 京都大学化学研究所 生体機能化学研究系 生体触媒化学研究領域 助教
専門分野
    有機合成化学
主な研究テーマ
  1. 生物活性化合物の合成と応用
  2. 酵素阻害剤の開発と応用
主な論文・著書
  1. Watanabe, B.; Tabuchi, Y.; Wada, K.; Hiratake, J., Synthesis and Evaluation of the Inhibitory Activity of the Four Stereoisomers of the Potent and Selective Human γ-Glutamyl Transpeptidase Inhibitor GGsTop Bioorg. Med. Chem. Lett. in press, (2017)
  2. Lee, H. J.; Watanabe, B.; Nakayasu, M.; Onjo, M.; Sugimoto, Y; Mizutani, M., Novel Steroidal Saponins from Dioscorea esculenta (Togedokoro) Biosci. Biotechnol. Biochem. in press, (2017)
  3. Watanabe, B.; Morikita, T.; Tabuchi, Y.; Kobayashi, R.; Li, C.; Yamamoto, M.; Koeduka, T.; Hiratake, J., An Improved Synthesis of the Potent and Selective γ-Glutamyl Transpeptidase Inhibitor GGsTop together with an Inhibitory Activity Evaluation of its Potential Hydrolysis Products Tetrahedron Lett. 58, 3700-3703 (2017)
  4. Watanabe, B.; Yamamoto, S.; Yokoi, T.; Sugiura, A.; Horoiwa, S.; Aoki, T.; Miyagawa, H.; Nakagawa, Y., Brassinolide-Like Activity of Castasterone Analogs with Varied Side Chains Against Rice Lamina Inclination Bioorg. Med. Chem. 25, 4566-4578 (2017)  [pubmed]
  5. Tokunaga, T.; Watanabe, B.; Sato, S.; Kawamoto, J.; Kurihara, T., Synthesis and Functional Assessment of a Novel Fatty Acid Probe, omega-Ethynyl Eicosapentaenoic Acid Analog, to Analyze the in Vivo Behavior of Eicosapentaenoic Acid Bioconjug. Chem. 28, 2077-2085 (2017)  [pubmed]
  6. Nakayasu, M.; Umemoto, N.; Ohyama, K.; Fujimoto, Y.; Lee, H. J.; Watanabe, B.; Muranaka, T.; Saito, K.; Sugimoto, Y.; Mizutani, M., A Dioxygenase Catalyzes Steroid 16alpha-Hydroxylation in Steroidal Glycoalkaloid Biosynthesis Plant Physiol. 175, 120-133 (2017)  [pubmed]
  7. Kamiyama, A.; Nakajima, M.; Han, L.; Wada, K.; Mizutani, M.; Tabuchi, Y.; Kojima-Yuasa, A.; Matsui-Yuasa, I.; Suzuki, H.; Fukuyama, K.; Watanabe, B.; Hiratake, J., Phosphonate-Based Irreversible Inhibitors of Human γ-Glutamyl Transpeptidase (GGT). GGsTop is a Non-Toxic and Highly Selective Inhibitor with Critical Electrostatic Interaction with an Active-Site Residue Lys562 for Enhanced Inhibitory Activity Bioorg. Med. Chem. 24, 5340-5352 (2016)  [pubmed]
  8. Watanabe, B., Structure-Activity Relationship Studies of Insect and Plant Steroid Hormones. J. Pestic. Sci. 40, 146-151 (2015)
  9. Watanabe, B.; Minami, S.; Ishida, H.; Yoshioka, R.; Nakagawa, Y.; Morita, T.; Hayashi, K., Stereospecific Inhibitory Effects of CCG-1423 on the Cellular Events Mediated by Myocardin-Related Transcription Factor A. PLoS One 10, e0136242 (2015)  [pubmed]
  10. Watanabe, B.; Ichiyanagi, A.; Hirokawa, K.; Gomi, K.; Nakatsu, T.; Kato, H.; Kajiyama, N., Synthesis and Inhibitory Activity of Substrate-Analog Fructosyl Peptide Oxidase Inhibitors. Bioorg. Med. Chem. Lett. 25, 3910-3913 (2015)  [pubmed]
  11. 渡辺文太;平竹潤, グルタチオン代謝とチオールケミストリー 化学と生物 53, 354 - 361 (2015)
  12. Kodan, A.; Yamaguchi, T.; Nakatsu, T.; Sakiyama, K.; Hipolito, C. J.; Fujioka, A.; Hirokane, R.; Ikeguchi, K.; Watanabe, B.; Hiratake, J.; Kimura, Y.; Suga, H.; Ueda, K.; Kato, H., Structural Basis for Gating Mechanisms of a Eukaryotic P-Glycoprotein Homolog. Proc. Natl. Acad. Sci. U. S. A. 111, 4049-4054 (2014)  [pubmed]
  13. Hayashi, K.; Watanabe, B.; Nakagawa, Y.; Minami, S.; Morita, T., RPEL Proteins Are the Molecular Targets for CCG-1423, an Inhibitor of Rho Signaling. PLoS One 9, e89016 (2014)  [pubmed]
  14. Nakajima, M.; Watanabe, B.; Han, L.; Shimizu, B.; Wada, K.; Fukuyama, K.; Suzuki, H.; Hiratake, J., Glutathione-Analogous Peptidyl Phosphorus Esters as Mechanism-Based Inhibitors of γ-Glutamyl Transpeptidase for Probing Cysteinyl-Glycine Binding Site. Bioorg. Med. Chem. 22, 1176-1194 (2014)  [pubmed]
  15. Koeduka, T.; Sugimoto, K.; Watanabe, B.; Someya, N.; Kawanishi, D.; Gotoh, T.; Ozawa, R.; Takabayashi, J.; Matsui, K.; Hiratake, J., Bioactivity of Natural O-Prenylated Phenylpropenes from Illicium anisatum Leaves and their Derivatives Against Spider Mites and Fungal Pathogens. Plant Biol. 16, 451-456 (2014)  [pubmed]
  16. Iijima, Y.; Watanabe, B.; Sasaki, R.; Takenaka, M.; Ono, H.; Sakurai, N.; Umemoto, N.; Suzuki, H.; Shibata, D.; Aoki, K., Steroidal Glycoalkaloid Profiling and Structures of Glycoalkaloids in Wild Tomato Fruit. Phytochem. 95, 145-157 (2013)  [pubmed]
  17. Koeduka, T.; Suzuki, S.; Iijima, Y.; Ohnishi, T.; Suzuki, H.; Watanabe, B.; Shibata, D.; Umezawa, T.; Pichersky, E.; Hiratake J., Enhancement of Production of Eugenol and its Glycosides in Transgenic Aspen Plants via Genetic Engineering. Biochem. Biophys. Res. Commun. 436, 73-78 (2013)  [pubmed]
  18. Ikeuchi, H.; Ahn, Y. M.; Otokawa, T.; Watanabe, B.; Hegazy, L.; Hiratake, J.; Richards, N. G., A Sulfoximine-Based Inhibitor of Human Asparagine Synthetase Kills L-Asparaginase-Resistant Leukemia Cells. Bioorg. Med. Chem. 20, 5915-5927 (2012)  [pubmed]
  19. 田中亮輔;山本真也;渡辺文太;平竹潤;大喜多守;松村靖夫, 虚血性急性腎障害に対する新規選択的γ-glutamyl transpeptidase阻害薬GGsTopTMの改善効果について 腎とフリーラジカル 11, 146-149 (2013)
  20. Ishibashi, T.; Tomita, H.; Yokooji, Y.; Morikita, T.; Watanabe, B.; Hiratake, J.; Kishimoto, A.; Kita, A.; Miki, K.; Imanaka, T.; Atomi, H., A Detailed Biochemical Characterization of Phosphopantothenate Synthetase, a Novel Enzyme Involved in Coenzyme A Biosynthesis in the Archaea. Extremophiles 16, 819-828 (2012)  [pubmed]
  21. Sakamoto, T.; Ohnishi, T.; Fujioka, S.; Watanabe, B.; Mizutani, M., Rice CYP90D2 and CYP90D3 Catalyze C-23 Hydroxylation of Brassinosteroids in Vitro. Plant Physiol. Biochem. 58, 220-226 (2012)  [pubmed]
  22. Ohnishi, T.; Godza, B.; Watanabe, B.; Fujioka, S.; Hategan, L.; Ide, K.; Shibata, K.; Yokota, T.; Szekeres, M.; Mizutani, M., CYP90A1/CPD, a Brassinosteroid Biosynthetic Cytochrome P450 of Arabidopsis, Catalyzes C-3 Oxidation. J. Biol. Chem. 287, 31551-31560 (2012)  [pubmed]
  23. Sato, S.; Kawamoto, J.; Sato, S. B.; Watanabe, B.; Hiratake, J.; Esaki, N.; Kurihara, T., Occurrence of a Bacterial Membrane Microdomain at the Cell Division Site Enriched in Phospholipids with Polyunsaturated Hydrocarbon Chains. J. Biol. Chem. 287, 24113-24121 (2012)  [pubmed]
  24. 湯浅(小島)明子;林綸子;韓立友;渡辺文太;平竹潤;湯浅勲, γ-グルタミルトランスペプチダーゼ (GGT)阻害剤によるコラーゲンおよびエラスチン産生能の亢進効果とそのメカニズム 日本香粧品学会誌 36, 93-100 (2012)
  25. Yamamoto, S.; Watanabe, B.; Hiratake, J.; Tanaka, R.; Ohkita, M.; Matsumura, Y., Preventive Effect of GGsTop, a Novel and Selective γ-Glutamyl Transpeptidase Inhibitor, on Ischemia/Reperfusion-Induced Renal Injury in Rats. J. Pharmacol. Exp. Ther. 339, 945-951 (2011)  [pubmed]
  26. Koeduka, T.; Watanabe, B.; Suzuki, S.; Hiratake, J.; Mano, J.; Yazaki, K., Characterization of Raspberry Ketone/Zingerone Synthase, Catalyzing the alpha, beta-Hydrogenation of Phenylbutenones in Raspberry Fruits. Biochem. Biophys. Res. Commun. 412, 104-108 (2011)  [pubmed]
  27. Arai, H.; Watanabe, B.; Nakagawa, Y.; Miyagawa, H., Synthesis of Ponasterone A Derivatives with Various Steroid Skeleton Moieties, Evaluation of their Binding to the Ecdysone Receptor of Kc Cells. Steroids 73, 1452-1464 (2008)  [pubmed]
  28. Todoroki, Y.; Kobayashi, K.; Yoneyama, H.; Hiramatsu, S.; Jin, M -H.; Watanabe, B.; Mizutani, M.; Hirai, N., Structure-Activity Relationship of Uniconazole, a Potent Inhibitor of ABA 8′-Hydroxylase, with a Focus on Hydrophilic Functional Groups and Conformation. Bioorg. Med. Chem. 16, 3141-3152 (2008)  [pubmed]
  29. Murakami, K.; Watanabe, B.; Nishida, R.; Mori, N.; Kuwahara, Y., Identification of Crinosterol from Astigamatid Mites. Insect Biochem. Molecular Biol. 37, 506-511 (2007)  [pubmed]
  30. Ohnishi, T.; Szatmari, A. M.; Watanabe, B.; Fujita, S.; Bancos, S.; Koncz, C.; Lafos, M.; Shibata, K.; Yokota, T.; Sakata, K.; Szekeres, M.; Mizutani, M., C-23 Hydroxylation by Arabidopsis CYP90C1 and CYP90D1 Reveals a Bovel Shortcut in Brassinosteroid Biosynthesis. Plant Cell 18, 3275-3288 (2006)  [pubmed]
  31. Ohnishi, T.; Watanabe, B.; Sakata, K.; Mizutani, M., CYP724B2 and CYP90B3 Function in the Early C-22 Hydroxylation Steps of Brassinosteroid Biosynthetic Pathway in Tomato. Biosci. Biotechnol. Biochem. 70, 2071-2080 (2006)  [pubmed]
  32. Ohnishi, T.; Nomura, T.; Watanabe, B.; Ohta, D.; Yokota, T.; Miyagawa, H.; Sakata, K.; Mizutani, M., Tomato Cytochrome P450 CYP734A7 Functions in Brassinosteroid Catabolism. Phytochem. 67, 1895-1906 (2006)  [pubmed]
  33. Morikawa, T.; Mizutani, M.; Aoki, N.; Watanabe, B.; Saga, H.; Saito, S.; Oikawa, A.; Suzuki, H.; Sakurai, N.; Shibata, D.; Wadano, A.; Sakata, K.; Ohta, D., Cytochrome P450 CYP710A Encodes the Sterol C-22 Desaturase in Arabidopsis and Tomato. Plant Cell 18, 1008-1022 (2006)  [pubmed]
  34. Fujita, S.; Ohnishi, T.; Watanabe, B.; Yokota, T.; Takatsuto, S.; Fujioka, S.; Yoshida, S.; Sakata, K.; Mizutani, M., Arabidopsis CYP90B1 Catalyzes the Early C-22 Hydroxylation of C27, C28, and C29 Sterols. Plant J. 45, 765-774 (2006)  [pubmed]
  35. Yamamoto, S.; Watanabe, B.; Otsuki, J.; Nakagawa, Y.; Akamatsu, M.; Miyagawa, H., Synthesis of 26,27-Bisnorcastasterone Analogs and Analysis of Conformation-Activity Relationship for Brasssinolide-like Activity. Bioorg. Med. Chem. 14, 1761-1770 (2006)  [pubmed]
  36. Watanabe, B.; Nakagawa, Y.; Ogura, T.; Miyagawa, H., Stereoselective Synthesis of (22R)- and (22S)-Castasterone/Ponasterone A Hybrid Compounds and Evaluation of their Molting Hormone Activity. Steroids 69, 483-493 (2004)  [pubmed]
  37. Uesusuki, S.; Watanabe, B.; Yamamoto, S.; Otsuki, J.; Nakagawa, Y.; Miyagawa, H., Synthesis of Brassinosteroids of Varying Acyl Side Chains andEvaluation of their Brassinolide-like Activity Biosci. Biotechnol. Biochem. 68, 1097-1105 (2004)  [pubmed]
  38. Watanabe, B.; Yamamoto, S.; Sasaki, K.; Nakagawa, Y.; Miyagawa, H., A Simple Synthesis of 6-Deoxoteasterone and its 20-Epimer. Tetrahedron Lett. 45, 2767-2769 (2004)
  39. Watanabe, B.; Nakagawa, Y.; Miyagawa, H., Synthesis of a Castasterone/Ponasterone Hybrid Compound and Evaluation of its Molting Hormone-like Activity. J. Pestic. Sci. 28, 188-193 (2003)
  40. Miyagawa, H.; Okada, M.; Uemura, I.; Watanabe, B.; Ueno, T., A Chemical Approach for Elucidating the Molecular Interaction of Host-Specific AK-Toxin with Japanese Pear. Advances in Microbial Toxin Research and its Biotechnological Exploitation (Kluwer Academic/Plenum Publishers) 1-21 (2002)


Update: Sep 08,2017