Faculty Information, Institute for Chemical Research, Kyoto University   [ English | Japanese ]


TSUGE, Tomohiko

Division of Biochemistry - Molecular Biology -
（Laboratory in the Department of Biophysics, Division of Biological Science, Graduate School of Science）
Assistant Professor
Ph.D., The University of Tokyo
URL:http://molbio.kuicr.kyoto-u.ac.jp/mbl/index_e.html
E-mail: tsuge@scl.kyoto-u.ac.jp
Tel: 0774-38-3263
Fax: 0774-38-3259
Academic career
    1996.03Ph.D., Department of Biological Sciences, Graduate School of Science, The University of Tokyo
    1996.04 - 1997.11Frontier Researcher at RIKEN Institute, Wako Japan
    1997.11 - 2003.06Postdoctoral Researcher at Yale University, New Haven CT, USA
    2003.06 - 2004.03Postdoctoral Researcher at National Institute of Agrobiological Sciences, Tsukuba Japan
    2004.04 - presentAssistant Professor, Institute for Chemical Research, Kyoto University
    2005.01 - presentalso Invited Scientist at RIKEN Institute, Wako Japan
    2006.03 - 2007.02also Guest Professor at BK-21 Silver-Bio Research Center, Dong-A University, Busan Korea
    2006.07 - 2007.03also Invited Lecturer at Ono High School, Hyogo Japan
    2008.07 - 2012.03also Invited Lecturer at Ono High School, Hyogo Japan
Research field
    Molecular Biology
Current research
  1. Development in Higher Plants (Photomorphogenesis, Leaf Development)
  2. Signal Transduction
  3. Protein Degradation Regulation
Selected publications
  1. Aki S, Nakai H, Aoyama T, Oka A, Tsuge T*., AtSAP130/AtSF3b-3 function is required for reproduction in Arabidopsis thaliana. Plant Cell Physiol 52, 1330-9 (2011). [0 times cited]  [pubmed]
  2. Tsuge T*, Menon S, Tong Y, Wei N., CSN1 inhibits c-Jun phosphorylation and down-regulates ectopic expression of JNK1. Protein Cell 2, 423-32 (2011). [0 times cited]  [pubmed]
  3. Luo Y, Qin G, Zhang J, Liang Y, Song Y, Zhao M, Tsuge T, Aoyama T, Liu J, Gu H, Qu LJ*., D-myo-inositol-3-phosphate plays an essential role in auxin-regulated embryogenesis by affecting phosphatidylinositol-mediated endomembrane function in Arabidopsis. Plant Cell 23, 1352-72 (2011). [0 times cited]  [pubmed]
  4. Tsuge T, Aki S., Chapter1 Photoreceptors and light signal transduction. (in Japanese) "Latest Plant Physiological Chemistry", Daigaku-kyouiku-shuppan Okayama, pp 23-50 (2011).
  5. She KC, Kusano H, Koizumi K, Yamakawa H, Hakata M, Imamura T, Fukuda M, Naito N, Tsurumaki Y, Yaeshima M, Tsuge T, Matsumoto K, Kudoh M, Itoh E, Kikuchi S, Kishimoto N, Yazaki J, Ando T, Yano M, Aoyama T, Sasaki T, Satoh H, Shimada H*., A novel factor FLOURY ENDOSPERM2 is involved in regulation of rice grain size and starch quality. Plant Cell 22, 3280-94 (2010). [0 times cited]  [pubmed]
  6. Cho KH, Jo A, Tsuge T, Kim JC, Kim R, Yoon HS, Kim GT*., Comparative analysis of local green tea in Korea by STS-RFLP. J Life Sci 20, 1415-9 (2010). [citation not available]
  7. Cho KH, Lee EJ, Tsuge T, Jo A, Kim JC, Cheong GW, Yoon HS, Kim GT*., Comparative genomic analysis of Korean and Japanese green tea trees by using molecular markers. Can J Plant Sci 90, 293-8 (2010). [citation not available]
  8. Taniguchi YY, Taniguchi M, Tsuge T, Oka A, Aoyama T*., Involvement of Arabidopsis thaliana phospholipase Dζ2 in root hydrotropism through the suppression of root gravitropism. Planta 231, 491-7 (2010). [5 times cited]  [pubmed]
  9. Oka A, Tsuge T., Chapter3 Regulation of ploidy - aiming to create bigger and stronger plants. (in Japanese) "Toward Reforestation", Kaiseisha Ohtsu, pp 35-44 (2008).
  10. Liu J, Zhang Y, Qin G, Tsuge T, Sakaguchi N, Luo G, Sun K, Shi D, Aki S, Zheng N, Aoyama T, Oka A, Yang W, Umeda M, Xie Q, Gu H, Qu LJ*., Targeted degradation of ICK4/KRP6 by the RING type E3 ligases RHF1a and RHF2a is essential for mitotic cell cycle progression during Arabidopsis gametogenesis. Plant Cell 20, 1589-600 (2008). [33 times cited]  [pubmed]
  11. Li LC, Qin GJ, Tsuge T, Hou XH, Ding MY, Aoyama T, Oka A, Chen Z, Gu H, Zhao Y, Qu LJ*., SPOROCYTELESS modulates YUCCA expression to regulate the development of lateral organs in Arabidopsis. New Phytol 179, 751-64 (2008). [10 times cited]  [pubmed]
  12. Kusano H, Testerink C, Vermeer JE, Tsuge T, Shimada H, Oka A, Munnik T, Aoyama T*., The Arabidopsis phosphatidylinositol phosphate 5-Kinase PIP5K3 is a key regulator of root hair tip growth. Plant Cell 20, 367-80 (2008). [39 times cited]  [pubmed]
  13. Menon S, Tsuge T, Dohmae N, Takio K, Wei N*., Association of SAP130/SF3b-3 with Cullin-RING ubiquitin ligase complexes and its regulation by the COP9 signalosome. BMC Biochem 9, 1 (2008). [8 times citated]  [pubmed]
  14. Li L, Hou X, Tsuge T, Ding M, Aoyama T, Oka A, Gu H, Zhao Y, Qu LJ*., The possible action mechanisms of indole-3-acetic acid methyl ester in Arabidopsis. Plant Cell Rep 27, 575-84 (2008). [7 times cited]  [pubmed]
  15. Pick E, Lau OS, Tsuge T, Menon S, Tong Y, Dohmae N, Plafker SM, Deng XW, Wei N*., Mammalian DET1 regulates Cul4A activity and forms stable complexes with E2 ubiquitin-conjugating enzymes. Mol Cell Biol 27, 4708-19 (2007). [14 times cited]  [pubmed]
  16. Katou S, Kuroda K, Seo S, Yanagawa Y, Tsuge T, Yamazaki M, Miyao A, Hirochika H, Ohashi Y*., A calmodulin-binding mitogen-activated protein kinase phosphatase is induced by wounding and regulates the activities of stress-related mitogen-activated protein kinases in rice. Plant Cell Physiol 48, 332-44 (2007). [19 times cited]  [pubmed]
  17. Taniguchi M, Sasaki N, Tsuge T, Aoyama T*, Oka A., ARR1 directly activates cytokinin response genes that encode proteins with diverse regulatory functions. Plant Cell Physiol 48, 263-77 (2007). [17 times cited]  [pubmed]
  18. Tsuge T., The ubiquitin regulation in photomorphogenesis. (in Japanese) "Tanpakushitu Kakusan Koso", Kyoritsu, Tokyo Vol.51, No.10 Suppl., 1352-7 (2006).  [pubmed]
  19. Tsuge T., The unique auxin perception by SCF-mediated pathways. (in Japanese) "Tanpakushitu Kakusan Koso", Kyoritsu, Tokyo Vol.51, No.10 Suppl., 1358 (2006).
  20. Tsuge T, Tsukaya H., Shoot - The architecture of plant module. (in Japanese) "Plantmimetics - learning from plants", NTS, Tokyo pp 4-10. (2006).
  21. Imai KK, Ohashi Y, Tsuge T, Yoshizumi T, Matsui M, Oka A, Aoyama T*., The A-type cyclin CYCA2;3 is a key regulator of ploidy levels in Arabidopsis endoreduplication. Plant Cell 18, 382-96 (2006). [54 times cited]  [pubmed]
  22. Tsuge T, Oka A., "Latest Topics" Will the research in plant light signaling contribute to the cure of cancer? ?The frontier research of COP9 Signalosome. (in Japanese) "Chemistry", Kagakudojin, Kyoto Vol.60, 72-3 (2005).
  23. Tsuge T., COP9 Signalosome is involved in morphogenesis and responses to environmental stimuli. (in Japanese) "Crosstalk between adaptive responses to environmental stimuli and morphogenesis in plants.", Springer-Verlag, Tokyo 163-9 (2004).
  24. Serino G, Su H, Peng Z, Tsuge T, Wei N, Gu H, Deng XW*., Characterization of the last subunit of the Arabidopsis COP9 signalosome: implications for the overall structure and origin of the complex. Plant Cell 15, 719-31 (2003). [29 times cited]  [pubmed]
  25. Yang X, Menon S, Lykke-Andersen K, Tsuge T, Di Xiao, Wang X, Rodriguez-Suarez RJ, Zhang H, Wei N*., The COP9 signalosome inhibits p27(kip1) degradation and impedes G1-S phase progression via deneddylation of SCF Cul1. Curr Biol 12, 667-72 (2002). [73 times cited]  [pubmed]
  26. Kim GT, Shoda K, Tsuge T, Cho KH, Uchimiya H, Yokoyama R, Nishitani K, Tsukaya H*., The ANGUSTIFOLIA gene of Arabidopsis, a plant CtBP gene, regulates leaf-cell expansion, the arrangement of cortical microtubules in leaf cells and expression of a gene involved in cell-wall formation. EMBO J 21, 1267-79 (2002). [105 times cited]  [pubmed]
  27. Tsukaya H*, Tsuge T., Morphological adaptation of inflorecences in plants that develop at low temperatures in early spring : the convergent evolution of "downy plants". Plant Biol 3, 536-43 (2001). [13 times cited]
  28. Lyapina S, Cope G, Shevchenko A, Serino G, Tsuge T, Zhou C, Wolf DA, Wei N, Shevchenko A, Deshaies RJ*., Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome. Science 292, 1382-5 (2001). [342 times cited]  [pubmed]
  29. Tsuge T, Matsui M, Wei N*., The subunit 1 of the COP9 signalosome suppresses gene expression through its N-terminal domain and incorporates into the complex through the PCI domain. J Mol Biol 305, 1-9 (2001). [52 times cited]  [pubmed]
  30. Tsuge T, Inagaki N, Yoshizumi T, Shimada H, Kawamoto T, Matsuki R, Yamamoto N, Matsui M*., Phytochrome-mediated control of COP1 gene expression in rice plants. Mol Genet Genomics 265, 43-50 (2001). [7 times cited]  [pubmed]
  31. Serino G, Tsuge T, Kwok S, Matsui M, Wei N, Deng XW*., Arabidopsis cop8 and fus4 mutations define the same gene that encodes subunit 4 of the COP9 signalosome. Plant Cell 11, 1967-80 (1999). [65 times cited]  [pubmed]
  32. Karniol B, Yahalom A, Kwok S, Tsuge T, Matsui M, Deng XW, Chamovitz DA*., The Arabidopsis homologue of an eIF3 complex subunit associates with the COP9 complex. FEBS Lett 439, 173-9 (1998). [35 times cited]  [pubmed]
  33. Kwok SF, Solano R, Tsuge T, Chamovitz DA, Ecker JR, Matsui M, Deng XW*., Arabidopsis homologs of a c-Jun coactivator are present both in monomeric form and in the COP9 complex, and their abundance is differentially affected by the pleiotropic cop/det/fus mutations. Plant Cell 10, 1779-90 (1998). [99 times cited]  [pubmed]
  34. Shibata D, Seki M, Mitsukawa N, Hayashida N, Ito T, Taji T, Tsuge T, Matsui M, Anai T, Liu YG, Whittier RF, Shinozaki K*., Establishment of framework P1 clones for map-based cloning and genome sequencing: direct RFLP mapping of large clones. Gene 225, 31-8 (1998). [1 times cited]  [pubmed]
  35. Wei N, Tsuge T, Serino G, Dohmae N, Takio K, Matsui M, Deng XW*., The COP9 complex is conserved between plants and mammals and is related to the 26S proteasome regulatory complex. Curr Biol 8, 919-22 (1998). [164 times cited]  [pubmed]
  36. Anai T, Kono N, Takai R, Tsuge T, Matsui M, Kosemura S, Yamamura S, Hasegawa K*., Nucleotide sequence of oat (Avena sativa L.) cDNA encoding an auxin-binding protein (ABP1). DNA Seq 8, 235-9 (1998). [0 times cited]  [pubmed]
  37. Anai T, Miyata M, Kosemura S, Yamamura S, Tsuge T, Matsui M, Uchida H, Hasegawa K*., Comparison of abp1 primary sequences from monocotyledonous and dicotyledonous species. J Plant Physiol 151, 446-9 (1997). [8 times cited]
  38. Tsuge T, Tsukaya H*, Uchimiya H., Two independent and polarized processes of cell elongation regulate leaf blade expansion in Arabidopsis thaliana (L.) Heynh. Development 122, 1589-600 (1996). [187 times cited]  [pubmed]
  39. Tsukaya H*, Tsuge T, Kim GT, Uchimiya H., Genetic analysis of cell-expansion processes in leaves of Arabidopsis thaliana. Plant Morph 7, 11-7 (1995). [citation not available]
  40. Tsukaya H*, Tsuge T, Uchimiya H., The cotyledon: A superior system for studies of leaf development. Planta 195, 309-12 (1994). [68 times cited]
  41. Kidou S, Umeda M, Tsuge T, Kato A, Uchimiya H*., Isolation and characterization of a rice cDNA similar to the S-phase-specific cyc07 gene. Plant Mol Biol 24, 545-7 (1994). [9 times cited]  [pubmed]
  42. Tsuge T, Tsukaya H*., Leaf development in dicotyledons - A genetic approach using the model plant, Arabidopsis. (in Japanese) Acta Phytotax Geobot 45, 151-64 (1994).
  43. Kidou S, Anai T, Umeda M, Aotsuka S, Tsuge T, Kato A, Uchimiya H*., Molecular structure of ras-related small GTP-binding protein genes of rice plants and GTPase activities of gene products in Escherichia coli. FEBS Lett 332, 282-6 (1993). [18 times cited]  [pubmed]
  44. Usami S*, Kirimura K, Tsuge T, Takahashi N., Continuous oxidization system of ferrous ion (Fe+) using a bio-reactor fixed with Thiobacillus ferrooxidans. (in Japanese) "Mizu-shori Gijutsu" 34, 163-6 (1993).　[citation not available]

Update: Apr 11,2012