京都大学化学研究所研究者情報   [ English | Japanese ]


柘植 知彦(つげ ともひこ)

生体機能化学研究系 生体分子情報
(理学研究科 生物科学専攻 生物物理学教室 協力講座)
准教授
博士(理学)
URL:http://www.scl.kyoto-u.ac.jp/~molbio/index.html
E-mail: tsuge@scl.kyoto-u.ac.jp
Tel: 0774-38-3263
Fax: 0774-38-3259

研究・教育歴
    1996.03: 東京大学大学院理学系研究科博士課程修了 東京大学・博士(理学)
    1996.04〜1997.11: 理化学研究所 フロンティア研究員
    1997.11〜2003.06: 米国 イェ−ル大学 博士研究員
    2003.06〜2004.03: 農業生物資源研究所 博士研究員
    2004.04〜2007.03: 京都大学化学研究所 助手
    2005.01〜現在: 理化学研究所 客員研究員(兼任)
    2006.03〜2007.02: 韓国 東亜大学 BK21 Silver-Bio研究センターGuest Professor(兼任)
    2006.07〜2007.03: 兵庫県立小野高等学校 特別非常勤講師(兼任)
    2008.07〜2015.03: 同上
    2007.04〜2013.11: 京都大学化学研究所 助教
    2013.12〜現在: 京都大学化学研究所 准教授
専門分野
    分子生物学
主な研究テーマ
  1. 高等植物の形態形成(光形態形成・葉形態形成)
  2. 環境応答と情報伝達
  3. タンパク質分解制御
主な論文・著書
  1. *Koeduka T, Kajiyama M, Furuta T, Suzuki H, Tsuge T, Matsui K., Characterization of an O-methyltransferase specific to guaiacol-type benzenoids from the flowers of loquat (Eriobotrya japonica). J Biosci Bioenglanta 122: 679-84 (2016).
  2. *Koeduka T, Kajiyama M, Suzuki H, Furuta T, Tsuge T, Matsui K., Benzenoid biosynthesis in the flowers of Eriobotrya japonica: molecular cloning and functional characterization of p-methoxybenzoic acid carboxyl methyltransferase. Planta 244: 725-36 (2016).
  3. Li N, Teranishi M, Yamaguchi H, Matsushita T, Watahiki MK, Tsuge T, Li SS, *Hidema J., UV-B-Induced CPD photolyase gene expression is regulated by UVR8-dependent and - independent pathways in Arabidopsis. Plant Cell Physiol 56: 2014-23 (2015).
  4. Wu Z, Zhu D, Lin X, Miao J, Gu L, Deng X, Yang Q, Sun K, Zhu D, Cao X, Tsuge T, Dean C, Aoyama T, Gu H, *Qu LJ., RNA binding proteins RZ-1B and RZ-1C play critical roles in regulating pre-mRNA splicing and gene expression during development in Arabidopsis Plant Cell 28: 55-73 (2016).
  5. Wada Y, Kusano H, Tsuge T, *Aoyama T, Phosphatidylinositol phosphate 5-kinase genes respond to phosphate deficiency for root hair elongation in Arabidopsis thaliana. Plant J 81: 426-437 (2015).
  6. Lin Q, Ohashi Y, Kato M, Tsuge T, Gu H, Qu LJ, *Aoyama T. , GLABRA2 directly suppresses basic helix-loop-helix transcription factor genes with diverse functions in root hair development. Plant Cell 27: 2894-906 (2015).
  7. Zhu D, Wu Z, Cao G, Li J, Wei J, Tsuge T, Gu H, Aoyama T, *Qu LJ., TRANSLUCENT GREEN, an ERF family transcription factor, controls water balance in Arabidopsis by activating the expression of aquaporin genes. Mol Plant 7, 601-15 (2014).
  8. Li R, Li J, Li S, Qin G, Novák O, Pěnčík A, Ljung K, Aoyama T, Liu J, Murphy A, Gu H, *Tsuge T, *Qu LJ., ADP1 affects plant architecture by regulating local auxin biosynthesis. PLoS Genet 10, e1003954. (2013).
  9. Franciosini A, Lombardi B, Iafrate S, Pecce V, Mele G, Lupacchini L, Kondou Y, Gusmaroli G, Aki S, Tsuge T, Deng XW, Matsui M, Vittorioso P, Costantino P, *Serino G., The Arabidopsis COP9 SIGNALOSOME INTERACTING F-BOX KELCH 1 protein forms an SCF ubiquitin ligase and regulates hypocotyl elongation. Mol Plant 6, 1616-29 (2013).
  10. *Pick E, Golan A, Zimbler JZ, Guo L, Sharaby Y, Tsuge T, Hofmann K, Wei N., The minimal deneddylase core of the COP9 signalosome excludes the Csn6 MPN- domain. PLoS One 7, e43980 (2012).  [pubmed]
  11. Aki S, Nakai H, Aoyama T, Oka A, *Tsuge T., AtSAP130/AtSF3b-3 function is required for reproduction in Arabidopsis thaliana. Plant Cell Physiol 52, 1330-9 (2011).  [pubmed]
  12. *Tsuge T, Menon S, Tong Y, Wei N., CSN1 inhibits c-Jun phosphorylation and down-regulates ectopic expression of JNK1. Protein Cell 2, 423-32 (2011).  [pubmed]
  13. Luo Y, Qin G, Zhang J, Liang Y, Song Y, Zhao M, Tsuge T, Aoyama T, Liu J, Gu H, *Qu LJ., D-myo-inositol-3-phosphate plays an essential role in auxin-regulated embryogenesis by affecting phosphatidylinositol-mediated endomembrane function in Arabidopsis. Plant Cell 23, 1352-72 (2011).  [pubmed]
  14. 柘植知彦, 安喜史織., 第1章 光受容体と光情報伝達. 「最新 植物生理化学」, 長谷川宏司・広瀬克利(編), 大学教育出版 岡山, pp 23-50 (2011).
  15. Tsuge T, Aki S., Chapter1 Photoreceptors and light signal transduction. (in Japanese) "Latest Plant Physiological Chemistry", Daigaku-kyouiku-shuppan Okayama, pp 23-50 (2011).
  16. She KC, Kusano H, Koizumi K, Yamakawa H, Hakata M, Imamura T, Fukuda M, Naito N, Tsurumaki Y, Yaeshima M, Tsuge T, Matsumoto K, Kudoh M, Itoh E, Kikuchi S, Kishimoto N, Yazaki J, Ando T, Yano M, Aoyama T, Sasaki T, Satoh H, *Shimada H., A novel factor FLOURY ENDOSPERM2 is involved in regulation of rice grain size and starch quality. Plant Cell 22, 3280-94 (2010).  [pubmed]
  17. Cho KH, Jo A, Tsuge T, Kim JC, Kim R, Yoon HS, *Kim GT., Comparative analysis of local green tea in Korea by STS-RFLP. J Life Sci 20, 1415-9 (2010).
  18. Cho KH, Lee EJ, Tsuge T, Jo A, Kim JC, Cheong GW, Yoon HS, *Kim GT., Comparative genomic analysis of Korean and Japanese green tea trees by using molecular markers. Can J Plant Sci 90, 293-8 (2010).
  19. Taniguchi YY, Taniguchi M, Tsuge T, Oka A, *Aoyama T., Involvement of Arabidopsis thaliana phospholipase Dζ2 in root hydrotropism through the suppression of root gravitropism. Planta 231, 491-7 (2010).  [pubmed]
  20. 岡穆宏, 柘植知彦., 第3章 倍数性の制御―大きくて丈夫な植物の創造に向けて. 「森をとりもどすために」, 林隆久(編), 海青社 大津, pp 35-44 (2008).
  21. Oka A, Tsuge T., Chapter3 Regulation of ploidy - aiming to create bigger and stronger plants. (in Japanese) "Toward Reforestation", Kaiseisha Ohtsu, pp 35-44 (2008).
  22. Liu J, Zhang Y, Qin G, Tsuge T, Sakaguchi N, Luo G, Sun K, Shi D, Aki S, Zheng N, Aoyama T, Oka A, Yang W, Umeda M, Xie Q, Gu H, *Qu LJ., Targeted degradation of ICK4/KRP6 by the RING type E3 ligases RHF1a and RHF2a is essential for mitotic cell cycle progression during Arabidopsis gametogenesis. Plant Cell 20, 1589-600 (2008).  [pubmed]
  23. Li LC, Qin GJ, Tsuge T, Hou XH, Ding MY, Aoyama T, Oka A, Chen Z, Gu H, Zhao Y, *Qu LJ., SPOROCYTELESS modulates YUCCA expression to regulate the development of lateral organs in Arabidopsis. New Phytol 179, 751-64 (2008).  [pubmed]
  24. Kusano H, Testerink C, Vermeer JE, Tsuge T, Shimada H, Oka A, Munnik T, *Aoyama T., The Arabidopsis phosphatidylinositol phosphate 5-Kinase PIP5K3 is a key regulator of root hair tip growth. Plant Cell 20, 367-80 (2008).  [pubmed]
  25. Menon S, Tsuge T, Dohmae N, Takio K, *Wei N., Association of SAP130/SF3b-3 with Cullin-RING ubiquitin ligase complexes and its regulation by the COP9 signalosome. BMC Biochem 9, 1 (2008).  [pubmed]
  26. Li L, Hou X, Tsuge T, Ding M, Aoyama T, Oka A, Gu H, Zhao Y, *Qu LJ., The possible action mechanisms of indole-3-acetic acid methyl ester in Arabidopsis. Plant Cell Rep 27, 575-84 (2008).  [pubmed]
  27. Pick E, Lau OS, Tsuge T, Menon S, Tong Y, Dohmae N, Plafker SM, Deng XW, *Wei N., Mammalian DET1 regulates Cul4A activity and forms stable complexes with E2 ubiquitin-conjugating enzymes. Mol Cell Biol 27, 4708-19 (2007).  [pubmed]
  28. Katou S, Kuroda K, Seo S, Yanagawa Y, Tsuge T, Yamazaki M, Miyao A, Hirochika H, *Ohashi Y., A calmodulin-binding mitogen-activated protein kinase phosphatase is induced by wounding and regulates the activities of stress-related mitogen-activated protein kinases in rice. Plant Cell Physiol 48, 332-44 (2007).  [pubmed]
  29. Taniguchi M, Sasaki N, Tsuge T, *Aoyama T, Oka A., ARR1 directly activates cytokinin response genes that encode proteins with diverse regulatory functions. Plant Cell Physiol 48, 263-77 (2007).  [pubmed]
  30. 柘植知彦., 植物の光形態形成とユビキチン. 「蛋白質 核酸 酵素 」8月号増刊ユビキチン-プロテアソーム系とオートファジー, 田中啓二・大隈良典(編), 共立出版 東京, 51, No.10, 1352-7 (2006).
  31. Tsuge T., The ubiquitin regulation in photomorphogenesis. (in Japanese) "Tanpakushitu Kakusan Koso", Kyoritsu, Tokyo Vol.51, No.10 Suppl., 1352-7 (2006).  [pubmed]
  32. 柘植知彦., オーキシン受容体の発見 -植物ホルモンが制御するSCF型ユビキチンリガーゼ-. 「蛋白質 核酸 酵素 」8月号増刊ユビキチン-プロテアソーム系とオートファジー, 田中啓二・大隈良典(編), 共立出版 東京, 51, No.10, 1358 (2006).
  33. Tsuge T., The unique auxin perception by SCF-mediated pathways. (in Japanese) "Tanpakushitu Kakusan Koso", Kyoritsu, Tokyo Vol.51, No.10 Suppl., 1358 (2006).
  34. 柘植知彦, 塚谷裕一., 植物のモジュールと配置 -シュート. 「プラントミメティクッス-植物に学ぶ-」, 甲斐昌一・森川弘道(監), エヌ・ティー・エス 東京, pp 4-10 (2006).
  35. Tsuge T, Tsukaya H., Shoot - The architecture of plant module. (in Japanese) "Plantmimetics - learning from plants", NTS, Tokyo pp 4-10. (2006).
  36. Imai KK, Ohashi Y, Tsuge T, Yoshizumi T, Matsui M, Oka A, *Aoyama T., The A-type cyclin CYCA2;3 is a key regulator of ploidy levels in Arabidopsis endoreduplication. Plant Cell 18, 382-96 (2006).  [pubmed]
  37. 柘植知彦, 岡穆宏. , 植物の光情報伝達の解明はがん治療に役立つか ーCOP9シグナロソーム研究の最前線. 月刊「化学」, 化学同人 京都, 60, 72-3 (2005).
  38. Tsuge T, Oka A., "Latest Topics" Will the research in plant light signaling contribute to the cure of cancer? ?The frontier research of COP9 Signalosome. (in Japanese) "Chemistry", Kagakudojin, Kyoto Vol.60, 72-3 (2005).
  39. 柘植知彦., COP9シグナロソームと形態形成・環境応答. 「植物の環境応答と形態形成のクロストーク」,岡穆宏・岡田清孝・篠崎和夫(編), Springer Verlag Tokyo 163-9 (2004).
  40. Tsuge T., COP9 Signalosome is involved in morphogenesis and responses to environmental stimuli. (in Japanese) "Crosstalk between adaptive responses to environmental stimuli and morphogenesis in plants.", Springer-Verlag, Tokyo 163-9 (2004).
  41. Serino G, Su H, Peng Z, Tsuge T, Wei N, Gu H, *Deng XW., Characterization of the last subunit of the Arabidopsis COP9 signalosome: implications for the overall structure and origin of the complex. Plant Cell 15, 719-31 (2003).  [pubmed]
  42. Yang X, Menon S, Lykke-Andersen K, Tsuge T, Di Xiao, Wang X, Rodriguez-Suarez RJ, Zhang H, *Wei N., The COP9 signalosome inhibits p27(kip1) degradation and impedes G1-S phase progression via deneddylation of SCF Cul1. Curr Biol 12, 667-72 (2002).  [pubmed]
  43. Kim GT, Shoda K, Tsuge T, Cho KH, Uchimiya H, Yokoyama R, Nishitani K, *Tsukaya H., The ANGUSTIFOLIA gene of Arabidopsis, a plant CtBP gene, regulates leaf-cell expansion, the arrangement of cortical microtubules in leaf cells and expression of a gene involved in cell-wall formation. EMBO J 21, 1267-79 (2002).  [pubmed]
  44. *Tsukaya H, Tsuge T., Morphological adaptation of inflorecences in plants that develop at low temperatures in early spring : the convergent evolution of "downy plants". Plant Biol 3, 536-43 (2001).
  45. Lyapina S, Cope G, Shevchenko A, Serino G, Tsuge T, Zhou C, Wolf DA, Wei N, Shevchenko A, *Deshaies RJ., Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome. Science 292, 1382-5 (2001).  [pubmed]
  46. Tsuge T, Matsui M, *Wei N., The subunit 1 of the COP9 signalosome suppresses gene expression through its N-terminal domain and incorporates into the complex through the PCI domain. J Mol Biol 305, 1-9 (2001).  [pubmed]
  47. Tsuge T, Inagaki N, Yoshizumi T, Shimada H, Kawamoto T, Matsuki R, Yamamoto N, *Matsui M., Phytochrome-mediated control of COP1 gene expression in rice plants. Mol Genet Genomics 265, 43-50 (2001).  [pubmed]
  48. Serino G, Tsuge T, Kwok S, Matsui M, Wei N, *Deng XW., Arabidopsis cop8 and fus4 mutations define the same gene that encodes subunit 4 of the COP9 signalosome. Plant Cell 11, 1967-80 (1999).  [pubmed]
  49. Karniol B, Yahalom A, Kwok S, Tsuge T, Matsui M, Deng XW, *Chamovitz DA., The Arabidopsis homologue of an eIF3 complex subunit associates with the COP9 complex. FEBS Lett 439, 173-9 (1998).  [pubmed]
  50. Kwok SF, Solano R, Tsuge T, Chamovitz DA, Ecker JR, Matsui M, *Deng XW., Arabidopsis homologs of a c-Jun coactivator are present both in monomeric form and in the COP9 complex, and their abundance is differentially affected by the pleiotropic cop/det/fus mutations. Plant Cell 10, 1779-90 (1998).  [pubmed]
  51. Shibata D, Seki M, Mitsukawa N, Hayashida N, Ito T, Taji T, Tsuge T, Matsui M, Anai T, Liu YG, Whittier RF, *Shinozaki K., Establishment of framework P1 clones for map-based cloning and genome sequencing: direct RFLP mapping of large clones. Gene 225, 31-8 (1998).  [pubmed]
  52. Wei N, Tsuge T, Serino G, Dohmae N, Takio K, Matsui M, *Deng XW., The COP9 complex is conserved between plants and mammals and is related to the 26S proteasome regulatory complex. Curr Biol 8, 919-22 (1998).  [pubmed]
  53. Anai T, Kono N, Takai R, Tsuge T, Matsui M, Kosemura S, Yamamura S, *Hasegawa K., Nucleotide sequence of oat (Avena sativa L.) cDNA encoding an auxin-binding protein (ABP1). DNA Seq 8, 235-9 (1998).  [pubmed]
  54. Anai T, Miyata M, Kosemura S, Yamamura S, Tsuge T, Matsui M, Uchida H, *Hasegawa K., Comparison of abp1 primary sequences from monocotyledonous and dicotyledonous species. J Plant Physiol 151, 446-9 (1997).
  55. Tsuge T, *Tsukaya H, Uchimiya H., Two independent and polarized processes of cell elongation regulate leaf blade expansion in Arabidopsis thaliana (L.) Heynh. Development 122, 1589-600 (1996).  [pubmed]
  56. *Tsukaya H, Tsuge T, Kim GT, Uchimiya H., Genetic analysis of cell-expansion processes in leaves of Arabidopsis thaliana. Plant Morph 7, 11-7 (1995).
  57. *Tsukaya H, Tsuge T, Uchimiya H., The cotyledon: A superior system for studies of leaf development. Planta 195, 309-12 (1994).
  58. Kidou S, Umeda M, Tsuge T, Kato A, *Uchimiya H., Isolation and characterization of a rice cDNA similar to the S-phase-specific cyc07 gene. Plant Mol Biol 24, 545-7 (1994).  [pubmed]
  59. Tsuge T, *Tsukaya H., Leaf development in dicotyledons - A genetic approach using the model plant, Arabidopsis. (in Japanese) Acta Phytotax Geobot 45, 151-64 (1994).
  60. Kidou S, Anai T, Umeda M, Aotsuka S, Tsuge T, Kato A, *Uchimiya H., Molecular structure of ras-related small GTP-binding protein genes of rice plants and GTPase activities of gene products in Escherichia coli. FEBS Lett 332, 282-6 (1993).  [pubmed]
  61. 宇佐美昭次*, 桐村光太郎, 柘植知彦, 高橋信之., 鉄酸化細菌の固定による第一鉄イオンの連続酸化. 水処理技術 34, 163-6 (1993).
  62. *Usami S, Kirimura K, Tsuge T, Takahashi N., Continuous oxidization system of ferrous ion (Fe+) using a bio-reactor fixed with Thiobacillus ferrooxidans. (in Japanese) "Mizu-shori Gijutsu" 34, 163-6 (1993).


Update: Jul 18,2017