Faculty Information, Institute for Chemical Research, Kyoto University   [ English | Japanese ]


Research Center for Elements Science - Synthetic Organotransformation -
(Laboratory in the Department of Energy and Hydrocarbon Chemistry)
Assistant Professor
Doctor of Science
E-mail: hatake@scl.kyoto-u.ac.jp
Tel: 0774-38-3184
Fax: 0774-38-3186

Academic career
    2005.3 Graduated from The University of Tokyo
    2005.3 Graduated from Dr. Course, The University of Tokyo
    2005.3 D. Sc., The University of Tokyo
    2005.4-2006.2 JSPS postdoctral fellow
    2005.4-2005.12 Postdoctoral fellow, University of Chicago
    2006.3- Assistant Professor, Institute for Chemical Research, Kyoto University
    2011.10- PRESTO researcher of Japan Science and Technology Agency (concurrent)
    2012.7- Elements Strategy Initiative for Catalysts and Batteries, Kyoto University
Research field
    Synthetic Organic Chemistry, Organometallic Chemistry, Computational Chemistry
Current research
  1. Design and Application of Novel Catalysts
  2. Synthesis and Application of Polycyclic Aromatic Compounds
Selected publications
  1. Hatakeyama, T.; Imayoshi, R.; Yoshimoto, Y.; Ghorai, S. K.; Jin, M.; Takaya, H.; Norisue, K.; Sohrin, Y.; Nakamura, M, Iron-Catalyzed Aromatic Amination for Nonsymmetrical Triarylamine Synthesis J. Am. Chem. Soc. 134, 20262-20265 (2012)
  2. Hatakeyama, T.; Hashimoto, S.; Oba, T.; Nakamura, M. , Azaboradibenzo[6]helicene: Carrier Inversion Induced by Helical Homochirality J. Am. Chem. Soc. 134, 19600–19603 (2012)
  3. Noda, D.; Sunada, Y.; Hatakeyama, T.; Nakamura, M.; Nagashima, H. , Iron Promoted Conjugate Addition: Implication of the Six-Centered Mechanism Based on the Isolation of the Iron-Enolate Intermediate Chem. Commun. 48, 12231-12233 (2012)
  4. Hatakeyama, T.; Hashimoto, T.; Kathriarachchi, K. K. A. D. S.; Zenmyo, T.; Seike, H.; Nakamura, M. , Iron-Catalyzed Alkyl-Alkyl Suzuki-Miyaura Coupling Angew. Chem. Int. Ed. 51, 8834–8837 (2012)
  5. Ghorai S. K.; Jin, M.; Hatakeyama, T.; Nakamura, M., Cross-Coupling of Non-Activated Chloroalkanes with Aryl Grignard Reagents in the Presence of Iron/N-Heterocyclic Carbene Catalysts Org. Lett. 14, 1066–1069 (2012)
  6. Hashimoto, T.; Hatakeyama, T.; Nakamura, M. , Stereospecific Cross-Coupling between Alkenylboronates and Alkyl Halides Catalyzed by Iron-Bisphosphine Complexes J. Org. Chem. 77, 1168–1173 (2012)
  7. Hatakeyama, T.; Hashimoto, S.; Seki, S.; Nakamura, M. , Synthesis of BN-fused Polycyclic Aromatics via Tandem Intramolecular Electrophilic Arene Borylation J. Am. Chem. Soc. 133, 18614-18617 (2011)
  8. Hatakeyama, T.; Okada, Y.; Yoshimoto, Y.; Nakamura, M., Tuning Chemoselectivity in Iron-Catalyzed Sonogashira-type Reaction Using a Bisphosphine Ligand with Peripheral Steric Bulk: Selective Alkynylation of Non-activated Alkyl Halides Angew. Chem., Int. Ed. 50, 10973-10976 (2011)
  9. Hatakeyama, T.; Fujiwara, Y.; Okada, Y.; Itoh, T.; Hashimoto, T.; Kawamura, S.; Ogata, K.; Takaya, H.; Nakamura, M., Kumada-Tamao-Corriu Coupling of Alkyl Halides Catalyzed by an Iron-Bisphosphine Complex Chem. Lett. 40, 1030-1032 (2011)
  10. Hatakeyama, T.; Hashimoto, S.; Nakamura, M., Tandem Phospha-Friedel-Crafts Reaction Toward Curved π-Conjugated Frameworks with a Phosphorus Ring Junction Org. Lett. 13, 2130-1233 (2011)
  11. Ishizuka, K.; Seike, H.; Hatakeyama, T.; Nakamura, M., Nickel-Catalyzed Alkenylative Cross-Coupling Reaction of Alkyl Sulfides J. Am. Chem. Soc. 132, 13117–13119 (2010).
  12. Hatakeyama, T.; Hashimoto, T.; Kondo, Y.; Fujiwara, Y.; Seike, H.; Takaya, H.; Tamada, Y.; Ono, T.; Nakamura, M., Iron-Catalyzed Suzuki-Miyaura Coupling of Alkyl Halides J. Am. Chem. Soc. 132, 10674-10676 (2010)
  13. Hatakeyama, T.; Yoshimoto, Y.; Ghorai, S. K.; Nakamura, M., Transition-Metal-Free Electrophilic Amination between Aryl Grignard Reagents and N-Chloroamines Org. Lett. 12, 1516-1519 (2010).
  14. Hatakeyama, T.; Nakagawa, N.; Nakamura, M. , Iron-Catalyzed Negishi Coupling Toward an Effective Olefin Synthesis Org. Lett. 11, 4496-4499 (2009).
  15. Hatakeyama, T.; Hashimoto, S.; Ishizuka, K.; Nakamura, M. , Highly Selective Biaryl Cross-Coupling Reactions between Aryl Halides and Aryl Grignard Reagents: A New Catalyst Combination of N-Heterocyclic Carbenes and Iron, Cobalt, and Nickel Fluorides J. Am. Chem. Soc. 131, 11949-11963 (2009).
  16. Noda, D.; Sunada, Y.; Hatakeyama, T.; Nakamura, M.; Nagashima, H., Effect of TMEDA on Iron-catalyzed Coupling Reactions of ArylMgX with Alkyl Halides J. Am. Chem. Soc. 131, 6078-6079 (2009).
  17. Kreutz, J. E.; Li, L.; Roach, S.; Hatakeyama, T.; Ismagilov, R. F. , Laterally Mobile, Functionalized Self-Assembled Monolayers at the Fluorous-Aqueous Interface in a Plug-Based Microfluidic System: Characterization and Testing with Membrane Protein Crystallization J. Am. Chem. Soc. 131, 6042-6043 (2009).
  18. Hatakeyama, T.; Kondo, Y.; Fujiwara, Y.; Takaya, H.; Ito, S.; Nakamura, E.; Nakamura, M. , Iron-Catalysed Fluoroaromatic Coupling Reactions under Catalytic Modulation with 1,2-Bis(diphenylphosphino)benzene Chem. Comm. 1216-1218 (2009).
  19. Hatakeyama, T.; Yoshimoto, Y.; Gabriel T.; Nakamura, M., Iron-Catalyzed Enyne Cross-Coupling Reaction Org. Lett. 10, 5341-5344 (2008).
  20. Hatakeyama, T.; Nakamura, M.; Nakamura, E., Diastereoselective Addition of Zincated Hydrazones to Alkenylboronates and Stereospecific Trapping of Boron/Zinc Bimetallic Intermediates by Carbon Electrophiles J. Am. Chem. Soc. 130, 15688-15701 (2008)
  21. Hatakeyama, T.; Nakamura, M., Iron-Catalyzed Selective Biaryl Coupling: Remarkable Suppression of Homocoupling by the Fluoride Anion J. Am. Chem. Soc. 129, 9844-9845 (2007).
  22. Endo, K.; Hatakeyama, T.; Nakamura, M.; Nakamura, E., Indium-Catalyzed 2-Alkenylation of 1,3-Dicarbonyl Compounds with Unactivated Alkynes J. Am. Chem. Soc. 129, 5264-5271 (2007).
  23. Hatakeyama, T.; Ito, S.; Yamane, H.; Nakamura, M.; Nakamura, E., Regioselective α-Alkylation of Ketones with Alkyl Chlorides and Fluorides via Highly Nucleophilic Magnesium Enamides Tetrahedron (special issue) 63, 8440-8448 (2007).
  24. Hatakeyama, T.; Chen, D. L.; Ismagilov, R. F., Microgram-Scale Testing of Reaction Conditions in Solution Using Nanoliter Plugs in Microfluidics with Detection by MALDI-MS J. Am. Chem. Soc. 128, 2518-2519 (2006).
  25. Hatakeyama, T.; Ito, S.; Nakamura, M.; Nakamura, E., Alkylation of Magnesium Enamide with Alkyl Chlorides and Fluorides J. Am. Chem. Soc. 127, 14192-14193 (2005).
  26. Nakamura, M.; Hatakeyama, T.; Hara, K.; Fukudome, H.; Nakamura, E., Sequential Coupling of Zincated Hydrazone, Alkenylboronate, and Electrophile That Creates Several Contiguous Stereogenic Centers J. Am. Chem. Soc. 126, 14344-14345 (2004).
  27. Nakamura, M.; Hatakeyama, T.; Nakamura, E., α-Alkylation of Ketones by Addition of Zinc Enamides to Unactivated Olefins J. Am. Chem. Soc. 125, 11820-11825 (2004).
  28. Nakamura, M.; Hatakeyama, T.; Hara, K.; Nakamura, E., Enantioselective Synthesis of α-Substituted Ketones by Asymmetric Addition of Chiral Zinc Enamides to 1-Alkenes J. Am. Chem. Soc. 125, 6362-6363 (2003).
  29. Nakamura, M.; Hara, K.; Hatakeyama, T.; Nakamura, E., Regioselective Allylzincation of Alkenylboronate Org. Lett. 3, 3137-3140 (2001)

Update: Apr 02,2018