Faculty Information, Institute for Chemical Research, Kyoto University   [ English | Japanese ]


HATA, Yasuo

Advanced Research Center for Beam Science - Structural Molecular Biology -
（Laboratory in the Graduate School of Human and Environmental Studies）
Professor
Doctor Science
URL:http://www.scl.kyoto-u.ac.jp/~hata/index.html
E-mail: hata@scl.kyoto-u.ac.jp
Tel: 0774-38-3040
Fax: 0774-38-3045
Academic career
    1979.3 Graduated from Dr. Course, Osaka UniversityD. Sc., Osaka University
    1979.4-1991.2 Assistant Professor, Osaka University
    1991.3-2002.3 Associate Professor, Kyoto University
    2002.4- Professor, Kyoto University
Research field
    Structural Biology, Protein Crystallography
Current research
  1. Structural-biology Studies of Protein Functions
  2. Structure-based Studies on Reaction Mechanism of Enzymes
  3. Structural Studies on Environment-adaption of Protein Molecules
  4. Structural-biology Studies on Intermolecular Interactions of Proteins
Selected publications
  1. Fujii T, Oikawa T, Muraoka I, Soda K, Hata Y, Crystallization and Preliminary X-ray Diffraction Studies of Tetrameric Malate Dehydrogenase from the Novel Antarctic Psychrophile Flavobacterium frigidimaris KUC-1 Acta Crystallogr. F63, 983-986 (2007)
  2. Mima J, Hayashida M, Fujii T, Narita Y, Hayashi R, Ueda M, Hata Y, Structure of the Carboxypeptidase Y Inhibitor Ic in Complex with the Cognate Proteinase Reveals a Novel Mode of the Proteinase-Protein Inhibitor Interaction J. Mol. Biol. 346, 1323-1334 (2005)
  3. Hata Y, Hayashida M, Fujii T, Mima J, Hayashi R, Ueda M, Structure and Inhibition Mode of Protein Ic in Complex with Carboxypeptidase Y Acta Cryst. A61 (Supplement), C190 (2005)
  4. Fujii T, Hayashida M, Hamasu M, Ishiguro M, Hata Y, Structures of Two Lectins from the Roots of Pokeweed (Phytolacca americana) Acta Cryst. D60, 665-673 (2004)
  5. Mima J, Hayashida M, Fujii T, Hata Y, Hayashi R and Ueda M, Crystallization and Preliminary X-ray Analysis of Carboxypeptidase Y Inhibitor IC Complexed with the Cognate Proteinase Acta Cryst. D60, 1622-1624 (2004)
  6. Mihara H, Fujii T, Kato S, Kurihara T, Hata Y, Esaki N, Structure of External Aldimine of Escherichia coli CsdB, an IscS/NifS Homolog: Implications for Its Specificity toward Selenocysteine J. Biochem. 131, 679-685 (2002)
  7. Hata Y, Fujii T, Hayashida Y, Aso Y, Ishiguro M, Crystal Structures of Three Lectins from the Roots of Pokeweed Acta Cryst. A58(Supplement), C292 (2002)
  8. Fujii T, Sakai H, Kawata Y, Hata Y, Crystal Structure of Thermostable Aspartase and Exploration of Functional Sites Aspartase Family Acta Cryst. A58(Supplement), C100 (2002)
  9. Fujii T, Hata Y, Crystal Structure Analysis of Thermostable Aspartase and Exploration of Functional Sites The Journal of Structural Biology Sakabe Project 8(2), 1-9 (2002)
  10. Miyatake H, Hata Y, Fujii T, Akutagawa T, Morihara K, Katsube Y, Crystal Structure of Alkaline Proterase from Pseudomonas aeruginosa IFO3455 Bull. Inst. Chem. Res., Kyoto University 72, 373-386 (1994).
  11. Miyatake H, Hata Y, Fujii T, Morihara K, Katsube Y, Crystal Structure Determination of Alkaline Protease from Pseudomonas aeruginosa Strain PAO1 Photon Factory Activity Report 1993 11, 108 (1994).
  12. Miyatake H, Hata Y, Fujii T, Hamada K, Morihara K, Katsube Y, Crystal Structure of the Unliganded Alkaline Proterase from Pseudomonas aeruginosa IFO3080 and Its Conformational Changes on Ligand Binding J. Biochem. 118, 474-479 (1995).
  13. Miyatake H, Hata Y, Fujii T, Hamada K, Morihara K, Katsube Y, X-Ray Structure of Alkaline Protease from Pseudomonas aeruginosa IFO3455 Photon Factory Activity Report 1994 12, 77 (1995).
  14. Watanabe K, Hata Y, Miyake K, Fujii T, Suzuki Y, X-Ray Crystal Structure Analysis of Oligo-1,6-glucosidase Complexed with an Inhibitor p-Nitrophenol Photon Factory Activity Report 1994 12, 347 (1995).
  15. Fujii T, Hata Y, Wakagi T, Tanaka N, Oshima T, Novel Zinc-binding Centre in Thermoacidophilic Archaeal Ferredoxins Nature Struct. Biol. 3, 834-837 (1996).
  16. Hisano T, Hata Y, Fujii T, Liu J Q, Kurihara T, Esaki N, Soda K, Crystal Structure of L-2-Haloacid Dehalogenase from Pseudomonas sp. YL. Anα/β hydrolase structure that is different from theα/β hydrolase fold J. Biol. Chem. 271, 20322-20330 (1996).
  17. Hisano T, Hata Y, Fujii T, Liu J Q, Kurihara T, Esaki N, Soda K, Crystallization and Preliminary X-Ray Crystallographic Studies on L-2-Haloacid Dehalogenase from Pseudomonas sp. YL Proteins: Struct. Func. Gen. 24, 520-522 (1996).
  18. Fujii T, Hata Y, Ohzeki M, Moriyama H, Wakagi T, Tanaka N, Oshima T, Refined Crystal Structure of Ferredoxin from Thermoacidophilic Archaeon Acta Cryst. A52, Suppl., C-233 (1996).
  19. Hata Y, Hisano T, Fujii T, Liu J-Q, Kurihara T, Esaki N, Soda K, Crystal Structure of L-2-Haloacid Dehalogenase from Pseudomonas sp. YL at 2.5Å Resolution Acta Cryst. A52, Suppl., C-121 (1996).
  20. Hamada K, Hata Y, Miyatake H, Fujii T, Amada F, Fukuyama K, Identification of Ca2+ ions bound to proteins using X-ray anomalous dispersion technique Acta Cryst. A52, C-134 (1996).
  21. Fujii T, Hata Y, Moriyama H, Tanaka N, Wakagi T and T. Oshima T, X-ray Crystallographic Identification of Zinc Ion in Thermoacidophilic Archaeal Ferredoxin Photon Factory Activity Report 1995 13, 324 (1996).
  22. Watanabe K, Hata Y, Fujii T, Suzuki Y, X-Ray Crystal Structure Analysis of Oligo-1,6-glucosidase Photon Factory Activity Report 1995 13, 60 (1996).
  23. Hisano T, Hata Y, Fujii T, Kurihara T, Esaki N,Soda K, X-Ray Crystal Structure Analysis of L-2-Haloacid Dehalogenase from Pseudomonas sp. YL Photon Factory Activity Report 1995 13, 65 (1996).
  24. Hata Y, Miyatake H, Fujii T, Morihara K, Crystal Structure Analysis of P. aeruginosa Alkaline Protease Complexed with Peptide Ligands Photon Factory Activity Report 1995 13, 79 (1996).
  25. Fujii T, Hata Y, Oozeki M, Moriyama H, Wakagi T, Tanaka N, Oshima T, The Crystal Structure of Zinc-Containing Ferredoxin from the Thermoacidphilic Archaeon Sulfolobus sp. Strain 7 Biochemistry 36, 1505-1513 (1997).
  26. Yamamoto A, Hara T, Tomoo K, Ishida T, Fujii T, Hata Y, Murata M, Kitamura K, Binding Mode of CA074, a Specific Irreversible Inhibitor, to Bovine Cathepsin B as Determined by X-Ray Crystal Analysis of the Complex J. Biochem. 121, 974-977 (1997).
  27. Tokioka K, Masuda S, Fujii T, Hata Y, Yamamoto Y, Asymmetric cycloaddition of anthrone with N-substituted maleimides with C2-chiral pyrrolidines Tetrahedron: Asymmetry 8, 101-107 (1997).
  28. Fujii T, Wakagi T, Hata Y, The Structure of a Thermoacidophilic Archaeal Ferredoxin with a Novel Zinc Binding Center Crucial for Thermostabilization J. Inorg. Biochem. 67, 264 (1997).
  29. Hata Y, Hisano T, Fujii T, Kurihara T, Esaki N, Soda K, Crsytal Structure of Pseudomonas sp. YL L-2-Haloacid Dehalogenase at 2.0Å Resolution Photon Factory Activity Report 1996 14, 120 (1997).
  30. Hamada K, Katsuya Y, Hata Y, Miyatake H, Fujii T, Amada F, Fukuyama K, Determination of Ca2+ Ions Bound to Proteins Using an Anomalous Scattering Effect of Ca Atom Photon Factory Activity Report 1996 14, 79 (1997).
  31. Li Y F, Hata Y, Fujii T, Hisano T, Nishihara M, Kurihara T, Esaki N, Structure of Reaction Intermediates of L-2-Haloacid Dehalogenase and Implications for the Reaction Mechanism J. Biol. Chem. 273, 15035-15044 (1998).
  32. Li Y F, Hata Y, Fujii T, Kurihara T, Esaki N, X-Ray Structure of a Reaction Intermediate of L-2-Haloacid Dehalogenase with L-2-Chloropropionamide J. Biochem. 124, 20-22 (1998).
  33. Yamamoto Y, Okajima T, Fukazawa Y, Fujii T, Hata Y, Sawada S, Conformational analysis of a fluorescent rotor, 6-(2,2-dicyanovinyl)-1(2-hydroxyethyl)-1,2,3,4-tetrahydroquinoline J. Chem. Soc, Perkin Trans. 2, 561-564 (1998).
  34. Hata Y, Li Y-F, Fujii T, Hisano T, Nishihara M, Kurihara T, Esaki, NX-Ray Crystal Structure of Reaction Intermediate of L-2-Haloacid Dehalogenase Photon Factory Activity Report 1996 15 Part B, 27 (1998).
  35. Mihara H, Maeda M, Fujii T, Kurihara T, Hata Y, Esaki N, A nifS-like Gene, csdB, Encodes an Escherichia coli Counterpart of Mammalian Selenocysteine Lyase: Gene cloning, purification, characterization and preliminary X-ray crystallographic studies J. Biol. Chem. 274, 14768-14772 (1999).
  36. Fujii T, Maeda M, Mihara H, Kurihara T, Esaki N, Hata Y, Structure of a NifS-like Protein from Escherichia coli Acta Cryst. A55(Supplement), Abstract P06.04.036 (1999).
  37. Hata Y, Li Y-F, Fujii T, Kurihara T, Esaki N, X-ray Crystallographic Analysis of the Catalytic Mechanism of L-2-Haloacid Dehalogenase Acta Cryst. A55 (Supplement), Abstract P06.04.037 (1999).
  38. Sakai H, Fujii T, Kawata Y, Hata Y, Crystallographic Studies of Thermostable Aspartase from Bacillus YM55 Photon Factory Activity Report 1998 16 Part B, 259 (1999).
  39. Hata Y, Li Y-F, Fujii T, Kurihara T, Esaki N, Crystal Structure of an Ester Intermediate Formed between L-2-Haloacid Dehalogenase and L-2-Chlorobutyrate Photon Factory Activity Report 1998 16 Part B, 275 (1999).
  40. Fujii T, Kurihara T, Esaki N, Hata Y, X-ray Crystal Structure Analysis of Each Reaction Step of Dehalogenase Enzyme Spring-8 User Experiment Report 3, 207 (1999).
  41. Fujii T, Maeda M, Mihara H, Kurihara T, Esaki N, Hata Y, Structure of a NifS Homologue: X-ray Structure Analysis of CsdB, an Escherichia coli Counterpart of Mammalian Selenocysteine Lyase Biochemistry 39, 1263-1273 (2000).
  42. Maruyama M, Kumagai T, Matoba Y, Hayashida M, Fujii T, Hata Y, Sugiyama M, Crystal Structures of the Transposon Tn5-carried Bleomycin Resistance Determinant Uncomplexed and Complexed with Bleomycin J. Biol. Chem. 276, 9992-9999 (2001).
  43. Fujii T, Sakai H, Kawata Y, Hata Y, Crystal structure of aspartase from Bacillus sp. YM55-1 Photon Factory Activity Report 2001 16 Part B, 174 (2002).
  44. Fujii T, Hayashida M, Ishiguro M, Hata Y, Crystal structures of two lectin isomers from the roots of pokeweed Photon Factory Activity Report 2001 16 Part B, 185 (2002).
  45. Kitano T, Sohrin Y., Hata Y, Wada H, Hori T, Ueda K, Improved Selectivity for Cu(II) of Methyl-Substituted Poly(pyrazolyl)-borates, [HB(3-Mepz)3]- and [B(3-Mepz)4]-, throughSteric Contact Bul. Chem. Soc. Jpn 76, 1365-1373 (2003)
  46. Fujii T, Sakai H, Kawata Y, Hata Y, Crystal Structure of Thermostable Aspartasae from Bacillus sp. YM55-1: Structure-based Exploration of Functional Sites in the Aspartase Family J. Mol. Biol. 328, 635-654 (2003)
  47. Hayashida M, Fujii T, Hamasu M, Ishiguro M, Hata Y, Crystallization and Preliminary X-ray Analysis of Lectin C from the Roots of Pokeweed (Phytolacca americana) Acta Cryst. D59, 1249-1252 (2003)
  48. Hayashida M, Fujii T, Hamasu M, Ishiguro M, Hata Y, Similarity between Protein-Protein and Protein-Carbohydrate Interactions, Revealed by Two Crystal Structures of Lectins from the Roots of Pokeweed J. Mol. Biol. 334, 551-565 (2003)

Update: Apr 02,2012