京都大学化学研究所研究者情報   [ English | Japanese ]


藤井 知実 (ふじい ともみ )

先端ビームナノ科学センター 原子分子構造
助教
博士(理学)
URL:
E-mail: fujii @ scl.kyoto-u.ac.jp
Tel: 0774-38-3258
Fax: 0774-38-3045

研究・教育歴
    1993.7 東京工業大学大学院生命理工学研究科博士課程中退
    1993.8〜 京都大学化学研究所助手
    1998.3 東京工業大学博士(理学)
専門分野
    構造生物学、タンパク質結晶学
主な研究テーマ
  1. タンパク質機能発現の構造生物学
  2. 酵素反応機構の構造基盤
  3. タンパク質分子耐熱性の構造学的研究
主な論文・著書
  1. Fujii T, Goda Y, Yoshida M, Oikawa T, Hata Y., Crystallization and preliminary X-ray diffraction studies of maleylacetate reductase from Rhizobium sp. strain MTP-10005. Acta Crystallogr Sect F Struct Biol Cryst Commun 64, 737-9 (2008)  [pubmed]
  2. Fujii T, Oikawa T, Muraoka I, Soda K, Hata Y., Crystallization and preliminary X-ray diffraction studies of tetrameric malate dehydrogenase from the novel Antarctic psychrophile Flavobacterium frigidimaris KUC-1. Acta Crystallogr Sect F Struct Biol Cryst Commun 63, 983-6 (2007)  [pubmed]
  3. Mima J, Hayashida M, Fujii T, Narita Y, Hayashi R, Ueda M, Hata Y, Structure of the Carboxypeptidase Y Inhibitor Ic in Complex with the Cognate Proteinase Reveals a Novel Mode of the Proteinase-Protein Inhibitor Interaction J. Mol. Biol. 346, 1323-1334 (2005)
  4. Fujii T, Hayashida M, Hamasu M, Ishiguro M, Hata Y, Structures of Two Lectins from the Roots of Pokeweed (Phytolacca americana) Acta Cryst. D60, 665-673 (2004).
  5. Fujii T, Sakai H, Kawata Y, Hata Y, Crystal Structure of Thermostable Aspartasae from Bacillus sp. YM55-1: Structure-based Exploration of Functional Sites in the Aspartase Family J. Mol. Biol. 328, 635-654 (2003)
  6. Hayashida M, Fujii T, Hamasu M, Ishiguro M, Hata Y, Similarity between Protein-Protein and Protein-Carbohydrate Interactions, Revealed by Two Crystal Structures of Lectins from the Roots of Pokeweed J. Mol. Biol. 334, 551-565 (2003)
  7. Mihara H, Fujii T, Kato S, Kurihara T, Hata Y, Esaki N, Structure of External Aldimine of Escherichia coli CsdB, an IscS/NifS Homolog: Implications for Its Specificity toward Selenocysteine J. Biochem. 131, 679-685 (2002)
  8. Fujii T, Maeda M, Mihara H, Kurihara T, Esaki N, Hata Y, Structure of a NifS Homologue: X-ray Structure Analysis of CsdB, an Escherichia coli Counterpart of Mammalian Selenocysteine Lyase Biochemistry 39, 1263-1273 (2000).
  9. Li Y F, Hata Y, Fujii T, Hisano T, Nishihara M, Kurihara T, Esaki N, Structure of Reaction Intermediates of L-2-Haloacid Dehalogenase and Implications for the Reaction Mechanism J. Biol. Chem. 273, 15035-15044 (1998).
  10. Li Y F, Hata Y, Fujii T, Kurihara T, Esaki N, X-Ray Structure of a Reaction Intermediate of L-2-Haloacid Dehalogenase with L-2-Chloropropionamide J. Biochem. 124, 20-22 (1998).
  11. Fujii T, Hata Y, Oozeki M, Moriyama H, Wakagi T, Tanaka N, Oshima T, The Crystal Structure of Zinc-Containing Ferredoxin from the Thermoacidphilic Archaeon Sulfolobus sp. Strain 7 Biochemistry 36, 1505-1513 (1997).
  12. Hisano T, Hata Y, Fujii T, Liu J Q, Kurihara T, Esaki N, Soda K, Crystal Structure of L-2-Haloacid Dehalogenase from Pseudomonas sp. YL. Anα/β hydrolase structure that is different from theα/β hydrolase fold J. Biol. Chem. 271, 20322-20330 (1996).
  13. Fujii T, Hata Y, Wakagi T, Tanaka N, Oshima T, Novel Zinc-binding Centre in Thermoacidophilic Archaeal Ferredoxins Nature Struct. Biol. 3, 834-837 (1996).
  14. Miyatake H, Hata Y, Fujii T, Hamada K, Morihara K, Katsube Y, Crystal Structure of the Unliganded Alkaline Proterase from Pseudomonas aeruginosa IFO3080 and Its Conformational Changes on Ligand Binding J. Biochem. 118, 474-479 (1995).


Update: Jul 18,2017