京都大学化学研究所研究者情報   [ English | Japanese ]


古田 巧(ふるた たくみ )

物質創製化学研究系 精密有機合成化学
(京都大学大学院薬学研究科 協力講座)
准教授
博士(薬学)
URL:http://fos.kuicr.kyoto-u.ac.jp/
E-mail: furuta@fos.kuicr.kyoto-u.ac.jp
Tel: 0774-38-3191
Fax: 0774-38-3197
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研究・教育歴
    1993.3 岡山大学薬学部製薬化学科卒業
    1995.3 岡山大学大学院薬学研究科修士課程薬学専攻修了
    1998.3 京都大学大学院薬学研究科博士後期課程研究指導認定退学
    1998.5 京都大学博士(薬学)
    1998.6~1999.11 奈良先端科学技術大学院大学物質科学教育研究センター、CREST 博士研究員
    1999.12~2001.6 米国コロンビア大学化学科博士研究員
    2001.7~2008.3 静岡県立大学薬学部助手(2007.4~助教に職位変更)
    2008.4~ 京都大学化学研究所准教授
専門分野
    有機合成化学、不斉合成、生物有機化学
主な研究テーマ
  1. パラジウム触媒ドミノ型反応を利用した機能性分子の合成
  2. 生理活性天然物の合成研究
  3. 膜蛋白質の生物有機化学的研究
主な論文・著書
  1. Baba, T.; Yamamoto, J.; Hayashi, K.; Sato, M.; Yamanaka, M.; Kawabata, T.; Furuta, T., Catalytic discrimination between formyl groups in regio- and stereoselective intramolecular cross-aldol reactions Chem. Sci. 54, 3791–3797 (2016)
  2. Tomohara, K.; Kasamatsu, K.; Yoshimura, T.; Furuta, T.; Kawabata, T., Asymmetric synthesis of multisubstituted dihydrobenzofurans by intramolecular conjugate addition of short-lived C-O axially chiral enolates Chem. Pharm. Bull. (in press)
  3. Yamada, T.; Suzuki, K.; Hirose, T.; Furuta, T.; Ueda, Y.; Kawabata, T.; Omura, S.; Sunazuka, T., Organocatalytic site-selective acylation of avermect in B2a, a unique endectocidal drug Chem. Pharm. Bull. (in press)
  4. Mishiro, K.; Takeuchi, H.; Furuta, T.; Kawabta, T., A concise access to C2-symmetric chiral 4-pyrrolidinopyridine catalysts with dual functional side chains Chem. Pharm. Bull. (in press)
  5. Furuta, T.; Kawabata, T., Chiral imidazoles and pyridines as asymmetric organocatalysts RSC Green Chemistry Series 41, 351-380 (2016)
  6. Koeduka, T.; Kajiyama, M.; Suzuki, H.; Furuta, T.; Tsuge, T.; Matsui, K., Benzenoid biosynthesis in the flowers of Eriobotrya japonica: molecular cloning and functional characterization of p-methoxybenzoic acid carboxyl methyltransferase Planta  (in press)
  7. Asakawa, T.; Kawabe, Y.; Yoshida, Ai; Aihara, Y.; Manabe, T.; Hirose, Y.; Sakurada, A.; Inai, M.; Hamashima, Y.; Furuta, T.; Wakimoto, T.; Kan, T., Syntheses of methylated catechins and theaflavins using 2-nitrobenzenesulfonyl group to protect and deactivate phenol J. Antibiot. 96, 299-312 (2016)
  8. Imayoshi, A.; Yamanaka, M.; Sato, M.; Yoshida, K.; Furuta, T.; Ueda, Y.; Kawabata, T., Insights into the Molecular Recognition Process in Organocatalytic Chemoselective Monoacylation of 1,5-Pentanediol Adv. Syn. Catal. 358, 1337-1344 (2016)
  9. Hyakutake, R.; Gondo, N.; Ueda, Y.; Yoshimura, .; Furuta, T.; Kawabata, T., Catalyst-controlled regiodivergent vinylogous aza-Morita-Baylis-Hillman reactions Tetrahedron Lett. 57, 1321-1324 (2016)
  10. Ueda, Y.; Furuta, T.; Kawabata, T., Final-stage site-selective acylation for the total syntheses of multifidosides A-C Angew. Chem. Int. Ed. 54, 11966–11970 (2015)
  11. Takeuchi, H.; Mishiro, K.; Ueda, Y.; Fujimori, Y.; Furuta, T.; Kawabata, T., Total synthesis of ellagitannins via regioselective sequential functionalization of unprotected glucose Angew. Chem. Int. Ed. 54, 6177–6180 (2015)
  12. Yamanaka, M.; Yoshida, U.; Sato, M.; Shigeta, T.; Yoshida, K.; Furuta, T.; Kawabata, T., Origin of high E-selectivity in 4-pyrrolidinopyridine-catalyzed tetrasubstituted α, α'-alkenediol: A computational and experimental study J. Org.Chem. 80, 3075–3082 (2015)
  13. Hirooka, Y.; Ikeuchi, K.; Kawamoto, Y.; Akao, Y.; Furuta, T.; Asakawa, T.; Inai, M.; Wakimoto, T.; Fukuyama, T.; Kan, T., Enantioselective synthesis of SB-203207 Org. Lett. 16, 1646-1649 (2014)
  14. Hamada, S.; Wada, Y.; Furuta, T.; Sasamori, T.; Tokitoh, N.; Kawabata, T., oxidatve kinetic resolution of racemic alkyl aryl carbinols by an electronically tuned chiral nitroxyl radical Tetrahedron Lett. 55, 1943-1945 (2014)
  15. Mishiro, K.; Furuta, T.; Sasamori, T.; Hayashi, K.; Tokitoh, N.; Futaki, S.; Kawabata, T., A cyclochiral conformational motif constructed using a robust hydrogen bonding network J. Am. Chem. Soc. 135, 13644-13647 (2013)
  16. Hamada, S.; Furuta, T.; Wada, Y.; Kawabata, T., Chemoselective oxidation by electronically tuned nitroxyl radical catalysts Angew. Chem. Int. Ed. 52, 8093-8097 (2013)
  17. Nishino, R.; Furuta, T.; Kan, K.; Sato, M.; Yamanaka, M.; Sasamori, T.; Tokitoh, N.; Kawabata, T., Investigation of the Carboxylate Position during the Acylation Reaction Catalyzed by Biaryl DMAP Derivatives with an Internal Carboxylate Angew. Chem. Int. Ed. 52, 6445-6449 (2013)
  18. Furuta, T.; Nikaido, M.; Yamamoto, J.; Kuribayashi, T.; Kawabata, T. , Synthesis of Axially Chiral Amino Acid Derivatives via the Selective Monoesterification of 1,1'-Biaryl-2,2'-dicarboxylic Acids Synthesis 45, 1312-1318 (2013)
  19. Furuta, T.; Kawabata, T., Desymmetrization of meso anhydride Comprehensive Chirality (Carreira, E. M. and Yamamoto, H. Ed.) Elsevier 5, 581-599 (2012)
  20. Yoshida, K.; Mishiro, K.; Ueda, Y.; Shigeta, T.; Furuta, T.; Kawabata, T., Nonenzymatic geometry-selective acylation of tri- and tetrasubstituted α,α’-alkenediols Adv. Syn. Catal. 354, 3291-3298 (2012)
  21. Schedel, H.; Kan, K.; Ueda, Y.; Mishiro, K.; Yoshida, K.; Furuta, T.; Kawabata, T., Asymmetric desymmetrization of meso-diols by C2-symmetric 4-pyrrolidinopyridines Beil. J. Org. Chem. 8, 1778-1787 (2012)
  22. Ueda, Y.; Mishiro, K.; Yoshida, K.; Furuta, T.; Kawabata, T., Regioselective diversification of a cardiac glycoside, lanatoside C, by organocatalysis J. Org. Chem. 77, 7850-7857 (2012)
  23. Yoshida, K.; Shigeta, T.; Furuta, T.; Kawabata, T., Catalyst-controlled reversal of chemoselectivity in acylation of 2-aminopentane1,5-diol derivatives Chem. Commun. 48, 6981–6983 (2012)
  24. Furuta, T.; Kawabata, T., Chiral DMAP-type catalysts for acyl-transfer reactions Science of Synthesis: Asymmetric Organicatalysis 1(List, B. Ed.) Georg Thieme Verlag KG (Stuttgart•New York) 497-546 (2012)
  25. Furuta, T., 酢酸および関連誘導体の化学 化学と教育 60, 434-437 (2012)
  26. Mabuchi, R.; Kurita, A.; Miyoshi, N.; Yokoyama, A.; Furuta, T.; Goda, T.; Suwa, Y.; Kan, T.; Amagai, T.; Ohshima, H., Analysis of Nε-ethyllysine in Human Plasma Proteins by Gas Chromatography-Negative Ion Chemical ionization/Mass Spectrometry as a Biomarker for Exposure to Acetaldehyde and Alcohol Alcohol.: Clin. Exp. Res. 36, 496-508 (2012)
  27. Yoshida K, Furuta T, Kawabata T, Organocatalytic Chemoselective Monoacylation of 1,n-Linear Diols Angew. Chem. Int. Ed. 50, 4888–4892 (2011)
  28. Higashi T, Isobe Y, Ouchi H, Okazaki Y, Asakawa T, Furuta T, Wakimoto T, Kan T, Stereocontrolled Synthesis of (+)-Methoxyphenylkainic acid and (+)-Phenylkainic acid Org. Lett. 13, 1089-1091 (2011)
  29. Yoshida A, Hirooka Y, Sugata Y, Nitta M, Manabe T, Ido S, Murakami K, Saha R K, Suzuki T, Ohshima M, Yoshida A, Itoh K, Shimizu K, Oku N, Furuta T, Asakawa T,Wakimoto T, Kan T, Concise Synthesis of Catechin Probes enabling Analysis and Imaging of EGCg Chem. Commun. 47, 1794-1796 (2011)
  30. Furuta, T, Yamamoto, J, Kitamura, Y, Hashimoto, A, Masu, H, Azumaya, I, Kan, T, Kawabata, T, Synthesis of Axially Chiral Amino Acid and Amino Alcohols via Additive-Ligand-Free Pd Catalyzed Domino Coupling Reaction and Subsequent Transformations of the Product Amidoaza[5]helicene J. Org. Chem. 75, 7010-7013 (2010)
  31. Yoshida K, Furuta T, Kawabata T, Perfectly Regioselective Acylation of a Cardiac Glycoside, Digitoxin, via Catalytic Amplification of the Intrinsic Reactivity Tetrahedron Lett. 51, 4830-4832 (2010)
  32. Ishii T, Mori T, Ichikawa T, Kaku M, Uekusa Y, Akagawa M, Aihara Y, Furuta T, Wakimoto T, Kan T, Nakayama T, Structural Characteristics of Green Tea Catechins for Formation of Protein Carbonyl in Human Serum Albumin Bioorg. Med. Chem. 18, 4892-4896 (2010)
  33. Asakawa T, Iinuma M, Wakasugi Y, Kuno M, Furuta T, Fujii S, Tanaka K, Kan T, Reaction Behavior of Cumulene: Diels-Alder, Friedel–Crafts, and Pd-Catalyzed Domino Reactions Heterocycles 80, 1125-1147 (2010)
  34. Ishii T, Minoda K, Bae M-J, Mori T, Uekusa Y, Ichikawa T, Aihara Y, Furuta T, Wakimoto T, Kan T, Nakayama T, Binding affinity of tea catechins for human serum albumin:Characterization by high-performance affinity chromatography with immobilized albumin column Mol. Nutr. Food Res. 54, 816-822 (2010)
  35. Muramatsu W, Mishiro K, Ueda Y, Furuta T, Kawabata T, Perfectly Regioselective and Sequential Protection of Glucopyranosides Eur. J. Org. Chem. 827-831 (2010)
  36. Furuta T, Onuki H, Mochizuki M,Ito M,Inai M, Wakimoto T, Kan T, Solid Support Synthesis of Artificial Phospholipids Synlett 3373-3377 (2009)
  37. Ueda Y, Muramatsu W, Mishiro K, Furuta T, Kawabata T, Functional Group Tolerance in Organocatalytic Regioselective Acylation of Carbohydrates J. Org. Chem. 74, 8802-8805 (2009)
  38. Kawabata, T, Furuta, T, Nonenzymatic Regioselective Acylation of Carbohydrates Chem. Lett. 38, 640-647 (2009)
  39. Aihara Y, Yoshida A, Furuta T, Wakimoto T, Akizawa T, Konishi M, Kan T, Regioselective Synthesis of Methylated Epigallocatechin Gallate via Nitrobenzenesulfonyl (Ns) Protecting Group Bioorg. Med. Chem. Lett. 4171-4174 (2009)
  40. Hidari K. I. P. J, Oyama, K, Ito, G, Nakayama, M, Inai, M, Goto, S, Kanai, Y, Watanabe, K, Yoshida, K, Furuta, T, Kan, T, Suzuki, T, Identification and characterization of flavonoids as sialyltransferase inhibitors Biochem. Biophys. Res. Commun. 382, 609-613 (2009)
  41. Furuta T, Nakayama M, Suzuki H, Tajimi H, Inai M, Nukaya H, Wakimoto T, Kan T , Concise synthesis of chafurosides A and B Org. Lett. 11, 2233-2236 (2009)
  42. Inai M, Goto T, Wakimoto T, Furuta T, Wakimoto T, Kan T , Stereocontrolled total synthesis of (-)-myriocin Tetrahedron:Asymmetry 19, 2771-2773 (2008)
  43. Koizumi Y, Kobayashi H, Wakimoto T, Furuta T, Fukuyama T, Kan T , Total synthesis of (-)-serotobenine J. Am. Chem. Soc. 130, 16854-16855 (2008)
  44. Hirooka Y, Nitta M, Furuta T, Kan T, Efficient synthesis of optically active gallocatechin-3-gallate derivatives via 6-endo cyclization Synlett 3234-3238 (2008)
  45. Furuta T, Mochizuki M, Ito M, Takahashi T, Suzuki T, Kan T , Versatile synthesis of head group functionalized phospholipids via oxime bond formation Org. Lett. 10, 4847-4850 (2008)
  46. Koizumi Y, Suzuki S, Takeda K, Murahashi K, Horikawa M, Katagiri K, Masu H, Kato T, Azumaya I, Fujii S, Furuta T, Tanaka K, Kan T , Synthesis and characteristic stereostructure of biphenanthryl ether Tetrahedron:Asymmetry 19, 1407-1410 (2008)
  47. Furuta T, Ueda M, YHirooka Y, Tanaka K, Kan T, Synthesis of diazirine possessing an acetophenone derivative as a valuable intermediate for a flavonoid photoaffinity probe Heterocycles 76, 811-817 (2008)
  48. Kitamura Y, Yoshikawa S, Furuta T, Kan T, One-pot synthesis of carbazole via tandem Suzuki-Miyaura and amination reaction Synlett 377-380 (2008)
  49. Kan T, Kawamoto Y, Asakawa T, Furuta T, Fukuyama T, Synthetic studies on altemicidin: Stereocontrolled construction of the core framework Org. Lett. 10, 169-171 (2008)
  50. Monguchi D, Ohta Y, Yoshiuchi T, Watanabe T, Furuta T, Tanaka K, Fuji K, Discrimination of carbonyl groups of meso-α-diketones with Horner-Wadsworth-Emmons reagent of chiral binaphthyl esters Tetrahedron 63, 12712-12719 (2007)
  51. T. Furuta, Y. Hirooka, A. Abe, Y. Sugata, M. Ueda, K. Murakami, T. Suzuki, K. Tanaka and T. Kan, Concise synthesis of dideoxy-epigallocatechin gallate (DO-EGCG) and evaluation of its anti-influenza virus activity Bioorg. Med. Chem. Lett. 17, 3095-3098 (2007)
  52. T. Furuta, Y. Kitamura, A. Hashimoto, S. Fujii, K. Tanaka and T. Kan, Efficient synthesis of phenanthridinone derivatives via a palladium-catalyzed coupling process Org. Lett. 9, 183-186 (2007)
  53. T. Furuta, T. Asakawa, M. Iinuma, S. Fujii, K. Tanaka and T. Kan, Domino Heck-C-H activation reaction of unsymmetrically substituted [3]cumulene Chem. Commun. 3648-3650 (2006)
  54. K. Tsubaki, H. Tanaka, K. Takaishi, M. Miura, H. Morikawa, T. Furuta, K. Tanaka, K. Fuji, T. Sasamori, N. Tokitoh, and T. Kawabata , Bottom-up synthesis of optically active oligonaphthalenes: Three different pathways for controlling axial chirality J. Org. Chem. 71, 6579-6587 (2006)
  55. T. Asakawa, M. Iinuma, T. Furuta, S. Fujii, T. Kan, and K. Tanaka, Reaction behavior of cumulene in Diels-Alder and Friedel-Crafts reactions Chem. Lett. 35, 512-513 (2006)
  56. Y. Kitamura, A. Hashimoto, S. Yoshikawa, J. Odaira, T. Furuta, T. Kan, and K. Tanaka, Synthesis of novel phenylnaphthyl phosphines and their applications to Pd-catalyzed amidation Synlett 115-117 (2006)
  57. T. Furuta, M. Sakai, H. Hayashi, T. Asakawa, F. Kataoka, S. Fujii, T. Suzuki, Y. Suzuki, K. Tanaka, N. Fishkin, and K. Nakanishi , Design and synthesis of artificial phospholipid for selective cleavage of integral membrane protein Chem. Commun. 4575-4577 (2005)
  58. T. Furuta, T. Kimura, S. Kondo, H. Mihara, T. Wakimoto, H. Nukaya, K. Tsuji, and K. Tanaka, Concise total synthesis of flavone C-glycoside having potent anti-inflammatory activity Tetrahedron 60, 9375-9379 (2004)
  59. T. Furuta, K. Tanaka, K. Tsubaki, and K. Fuji, Configurationally defined sexi- and octinaphthalene derivatives: synthesis and optical properties Tetrahedron 60, 4431-4441 (2004)
  60. S. Yoshikawa, J. Odaira, Y. Kitamura, A. V. Bedekar, T. Furuta, and K. Tanaka, Synthesis of novel 1-aryl-substituted 8-methoxynaphthalenes and their tendency for atropisomerization Tetrahedron 60, 2225-2234 (2004)
  61. K. Tsubaki, M. Miura, H. Morikawa, H. Tanaka, T. Kawabata, T. Furuta, K. Tanaka, and K. Fuji, Synthesis of optically active oligonaphthalenes via second-order asymmetric transformation J. Am. Chem. Soc. 125, 16200-16201 (2003)
  62. K. Tanaka, T. Furuta, and K. Fuji, Asymmetric carbonyl olefination in Modern Carbonyl Olefination (Ed.: T. Takeda), Wiley-VCH, Berlin (2003) Modern Carbonyl Olefination (Ed.: T. Takeda), Wiley-VCH, Berlin 286-342 (2003)
  63. K. Tsubaki, H. Tanaka, T. Furuta, K. Tanaka, T. Kinoshita, and K. Fuji, Use of meso-ternaphthalene derivatives: linear recognition of the α,ω-diamines by homoditopic receptors Tetrahedron 58, 5611-5617 (2002)
  64. Y. Fujimoto, J. Ishihara, S. Maki, N. Fujioka, T. Wang, T. Furuta, N. Fishkin, B. Borhan, N. Berova, and K. Nakanishi , On the bioactive conformation of the chromophore: Absolute sense of twist around 6-s-cis bond Chem. Eur. J. 7, 4198-4204 (2001)
  65. K. Fuji, T. Furuta, and K.Tanaka, Synthesis of configurationally defined sexi- and octinaphthalene derivatives Org. Lett. 3, 169-171 (2001)
  66. K. Tsubaki, H. Tanaka, T. Furuta, T. Kinoshita, K. Tanaka, and K. Fuji, Recognition of the chain length of α,ω-diamines by a meso-ternaphthalene derivative with two crown ethers Tetrahedron Lett. 41, 6089-6093 (2000)
  67. K. Fuji, T. Furuta, T. Otubo, and K. Tanaka, Hydrogen-bonded network with a unique structural unit having zeolite-like properties Tetrahedron Lett. 40, 3001-3004 (1999)
  68. K. Tanaka, T. Furuta, K. Fuji, Y. Miwa, and T. Taga, Preparation and absolute configuration of hexahydroxyter- and octahydroxyquater- naphthalene derivatives Tetrahedron:Asymmetry 7, 2199-2202 (1996)


Update: Jul 18,2017