京都大学化学研究所研究者情報   [ English | Japanese ]


佐藤 慎一(さとう しんいち)

生体機能化学研究系 ケミカルバイオロジー
准教授
博士(工学)
URL:
E-mail: ssato@scl.kyoto-u.ac.jp
Tel: 0774-38-3227
Fax: 0774-38-3226

研究・教育歴
    1999.8 京都工芸繊維大学工芸科学研究科博士後期課程単位取得退学
    2000.3 京都工芸繊維大学 博士(工学)
    1999.9-2004.3 京都大学エネルギー理工学研究所 博士研究員
    2004.4-2008.7 ベイラー医科大学 生化学・分子生物学科 博士研究員
    2008.8-2009.3 京都大学 物質-細胞統合システム拠点 博士研究員
    2009.4-2015.1 京都大学 物質-細胞統合システム拠点 助教
    2015.2-2017.1 京都大学 物質-細胞統合システム拠点 准教授
    2017.2 より現職
専門分野
    ケミカルバイオロジー、生物有機化学
主な研究テーマ
  1. 生理活性化合物の生体内標的タンパク質の同定
  2. 小分子化合物とRNAツールを利用した生体分子イメージング
  3. RNA G-quadruplex構造を標的とする小分子化合物の開発と利用
主な論文・著書
  1. Asano L., Watanabe M., Ryoden Y., Usuda Y., Yamaguchi T., Khambu B., Takashima M., Sato S., Sakai J., Nagasawa K., and Uesugi M., Vitamin D Metabolite, 25-Hydroxyvitamin D, Regulates Lipid Metabolism by Inducing Degradation of SREBP/SCAP Cell Chem. Biol. 24, 1-11 (2017)
  2. Mao D., Ando S., Sato S., Qin Y., Hirata N., Katsuda Y., Kawase E., Kuo T. F., Ueda K., Nakatsuji N., and Uesugi M., A Synthetic Hybrid Molecule for the Selective Removal of Human Pluripotent Stem Cells from Cell Mixtures. Angew. Chem. Int. Ed. 56, 1765-1770 (2017)
  3. Katsuda Y., Sato S.*, Asano L., Morimura Y., Furuta T., Hagihara M.*, Uesugi M.*, A Small Molecule That Represses Translation of G-Quadruplex-Containing mRNA. J. Am. Chem. Soc. 138(29), 9037−9040 (2016)
  4. Parvatkar P., Kato N., Uesugi M., Sato S., Ohkanda J., Intracellular generation of a diterpene-peptide conjugate that inhibits 14-3-3-mediated interactions. J. Am. Chem. Soc. 137(50), 15624−15627 (2015)
  5. Sato S.*, Watanabe M., Katsuda Y., Murata A., Wang D. O., Uesugi M.*, Live-Cell Imaging of Endogenous mRNAs with a Small Molecule. Angew. Chem. Int. Ed. 54(6), 1855-1858 (2015)
  6. 佐藤慎一,勝田陽介,上杉志成, ビオチン化体を利用した生化学的標的タンパク質精製法 化学同人 (2015)
  7. Frisco-Cabanos H. L., Watanabe M., Okumura N., Kusamori K., Takemoto N., Takaya J., Sato S., Yamazoe S., Takakura Y., Kinoshita S., Nishikawa M., Koizumi N., Uesugi M., Synthetic Molecules that Protect Cells from Anoikis and Their Use in Cell Transplantation. Angew. Chem. Int. Ed. 53(42), 11208-11213 (2014)
  8. Hirata N., Nakagawa M., Fujibayashi Y., Yamauchi K., Murata A., Minami I., Tomioka M., Kondo T., Kuo T. F., Endo H., Inoue H., Sato S., Ando S., Kawazoe Y., Aiba K., Nagata K., Kawase E., Chang Y. T., Suemori H., Eto K., Nakauchi H., Yamanaka S., Nakatsuji N., Ueda K., Uesugi M., A chemical probe that labels human pluripotent stem cells. Cell Rep. 6(6), 1165-1174 (2014)
  9. Murata, A., Sato, S., In vitro selection of RNA aptamers for a small-molecule dye. Methods Mol. Biol. 1111, 17-28 (2014)
  10. Sato, S., and Uesugi M., Affinity-based isolation of molecular targets of clinically used drugs. Case Studies in Chemical Biology 221-230 (2014)
  11. Takemoto, N., Suehara, T., Frisco, H. L., Sato, S., Sezaki, T., Kusamori, K., Kawazoe, Y., Park, S. M., Yamazoe, S., Mizuhata, Y., Inoue, R., Miller, G. J., Hansen, S. U., Jayson, G. C., Gardiner, J. M., Kanaya, T., Tokitoh, N., Ueda, K., Takakura, Y., Kioka, N., Nishikawa, M., and Uesugi, M., Small molecule-induced clustering of heparan sulfate promotes cell adhesion. J. Am. Chem. Soc. 135(30), 11032−11039 (2013)
  12. Murata, A.†, Sato, S.†, Kawazoe, Y., Uesugi M., Small-molecule fluorescent probes for specific RNA targets. Chem. Comm. 47(16), 4712 - 4714 (2011)
  13. Sato, S., Murata, A., Orihara, T., Shirakawa, T., Suenaga, K., Kigoshi, H., Uesugi, M., Marine Natural Product Aurilide Activates the OPA1-Mediated Apoptosis by Binding to Prohibitin. Chem. Biol. 18(1), 131–139 (2011)
  14. Shirakawa, T., Kawazoe, Y., Tsujikawa, T., Jung, D., Sato, S., Uesugi M., Deactivation of STAT6 through serine 707 phosphorylation by JNK. J. Biol. Chem. 286(5), 4003-4010 (2011)
  15. Sato, S., Murata, A., Shirakawa, T., Uesugi, M., Biochemical target isolation for novices: affinity-based strategies. Chem. Biol. 17(6), 616-623 (2010)
  16. 佐藤慎一, 村田亜沙子, 白川貴詩, 上杉志成, 生理活性物質による創薬標的同定のコツ 創薬研究のためのタンパク質・プロテオミクス解析 別冊, 141-146 (2010)
  17. Kamisuki, S., Mao, Q., Abu-Elheiga, L., Gu, Z., Kugimiya, A., Kwon, Y., Shinohara, T., Kawazoe, Y., Sato, S., Asakura, K., Choo, H., Sakai, J., Wakil, S., Uesugi, M., A small molecule that blocks fat synthesis by inhibiting the activation of SREBP. Chem. Biol. 16(8), 882-892 (2009)
  18. Yamazoe, S., Shimogawa, H., Sato, S., Uesugi, M., Discovery and Mechanism of Adhesamine, a Dumbbell-Shaped Small Molecule That Promotes Cell Adhesion. Chem. Biol. 16(7), 773-782 (2009)
  19. Jung, D., Shimogawa, H., Kwon, Y., Mao, Q., Sato, S., Kamisuki, S., Kigoshi, H., Uesugi, M., A Wrenchnolol Derivative Optimized for Gene Activation in Cells. J. Am. Chem. Soc. 131(13), 4774-4782 (2009)
  20. 佐藤慎一, 村田亜沙子, 上杉志成, 海洋天然物のケミカルジェネティクス 細胞工学 28(4), 332-337 (2009)
  21. Sato, S., Kwon, Y., Kamisuki, S., Srivastava, N., Mao, Q., Kawazoe, Y., Uesugi, M., Polyproline-Rod Approach to Isolating Protein Targets of Bioactive Small Molecules: Isolation of a New Target of Indomethacin. J. Am. Chem. Soc. 129(4), 873-880 (2007)
  22. Sato S., Murata A., Uesugi M., Identification of the cardiac beta-adrenergic receptor protein: solubilization and purification by affinity chromatography. Tanpakushitsu Kakusan Koso 52, 1782-1783 (2007)
  23. Murata A., Sato, S., Uesugi M., Chemical Genomics for Biomedicine. Saishin Igaku 9, 2205-2213 (2007)
  24. Konno, T., Morii, T., Hirata, A., Sato, S., Oiki, S., Ikura, K., Covalent blocking of fibril formation and aggrigation of intracellular amyloidgenic proteins by transglutaminase-catalyzed intramolecular cross-linking. Biochemistry 44(6), 2072-2079 (2005)
  25. Sato, S., Fukuda, M., Hagihara, M., Tanabe, Y., Ohkubo, K., Morii, T., Stepwise molding of a highly selective ribonucleopeptide receptor. J. Am. Chem. Soc. 127(1), 30-31 (2005)
  26. Sato, S., Uesugi M., Protein target identification on chemical genomics. Springer 77-90 (2005)
  27. Hagihara, M., Hasegawa, T., Sato, S., Yoshikawa, S., Ohkubo, K., Morii, T., Ribonucleopeptides: functional RNA-peptide complexes. Biopolymers 76(1), 66-68 (2004)
  28. Hagihara, M., Hasegawa, T., Tanabe, Y., Sato, S., Yoshikawa, S., Ohkubo, K., Morii, T., Design of sensing ribonucleopeptides for small ligands. Nucleic Acids Symp. Ser. (Oxf) 48, 33-34 (2004)
  29. Sato, S., Hasegawa, T., Hagihara, M., Fukuda, M., Ohkubo, K., Morii T., Optimization of an ATP-binding ribonucleopeptide receptor. Nucleic Acids Res. Suppl. 3, 239-240 (2003)
  30. Sato, S., Hagihara, M., Sugimoto, K., Morii, T., Chemical Approaches Untangling Sequence-Specific DNA Binding by Proteins. Chemistry - A European Journal 8(22), 5066-5071 (2002)
  31. Morii, T., Hagihara, M., Sato, S., Makino, K., In Vitro Selection of ATP-Binding Receptors Using a Ribonucleopeptide Complex. J. Am. Chem. Soc. 124(17), 4617-4623 (2002)
  32. Morii, T., Sato, S., Hagihara, M., Mori, Y., Imoto, K., Makino K., Structure-Based Design of a Leucine Zipper Protein with New DNA Contacting Region. Biochemistry 41, 2177-2183 (2002)
  33. Morii, T., Tanaka, T., Sato, S., Hagihara, M., Aizawa, Y., Makino K., A General Strategy To Determine a Target DNA Sequence of a Short Peptide: Application to a D-Peptide. J. Am. Chem. Soc. 124(2), 180-181 (2002)
  34. Sato, S., Honjyo, H., Tsuji, S., Hagihara, M., Makino, K., Morii, T., A new strategy to determine the target DNA sequence of a short peptide. Nucleic Acids Res. Suppl. 2, 205-206 (2002)
  35. Wu, X., Kamei K., Sato, H., Sato, S., Takano, R., Ichida, M., Mori, H., Hara, S., High-Level Expression of Human Acidic Fibroblast Growth Factor and Basic Fibroblast Growth Factor in Silkworm (Bombyx mori L.) Using Recombinant Baculovirus. Protein Expr. Purif. 21(1), 192-200 (2001)
  36. Kamei K., Sato, S., Hamato, N., Takano, R., Ohshima, K., Yamamoto, R., Nishino, R., Kato, H., Hara, S., Effect of P(2)' site tryptophan and P(20)' site deletion of Momordica charantia trypsin inhibitor II on inhibition of proteinases. Biochem. Biophys. Acta. 1480 (1-2), 6-12 (2000)
  37. Sato, S., Kamei K., Taniguchi, M., Sato, H., Takano, R., Mori, H., Ichida, M., Hara, S., Cloning and Expression of Momordica charantia Trypsin Inhibitor II Gene in Silkworm by using a Baculovirus Vector. Biosci. Biotech. Biochem. 64 (2), 393-398 (2000)
  38. Sato, S., Makino, K., Morii, T., DNA binding of a basic leucine-zipper protein with novel folding domain. Nucleic Acids Symp. Ser. 44, 13-14 (2000)
  39. Kamei K., Inoue, Y., Shiga, M., Sato, S., Takano, R., Hirayae, K., Hibi, T., Hara, S., Pectinolytic Enzymes from Pseudomonas Marginalis MAFF 03-01173. Phytochemistry 45 (7), 1359-1363 (1997)
  40. Kamei K., Sato, S., Takano, R., Tsujibo, H., Orikoshi, H., Imada, C., Okami, Y., Inamori, Y., Hara, S., Identification of the Positions of Disulfide Bonds of Chitinase from a Marine Bacterium, Alteromonas sp. Strain O-7. Biosci. Biotech. Biochem. 59(10), 1981-1982 (1995)


Update: Jul 18,2017